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3zym

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[[Image:3zym.jpg|left|200px]]
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==STRUCTURE OF CALM (PICALM) IN COMPLEX WITH VAMP8==
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<StructureSection load='3zym' size='340' side='right' caption='[[3zym]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3zym]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZYM FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zyl|3zyl]], [[1hg2|1hg2]], [[1hg5|1hg5]], [[1hfa|1hfa]], [[3zyk|3zyk]], [[1hf8|1hf8]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zym OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zym RCSB], [http://www.ebi.ac.uk/pdbsum/3zym PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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SNAREs provide a large part of the specificity and energy needed for membrane fusion and, to do so, must be localized to their correct membranes. Here, we show that the R-SNAREs VAMP8, VAMP3, and VAMP2, which cycle between the plasma membrane and endosomes, bind directly to the ubiquitously expressed, PtdIns4,5P(2)-binding, endocytic clathrin adaptor CALM/PICALM. X-ray crystallography shows that the N-terminal halves of their SNARE motifs bind the CALM(ANTH) domain as helices in a manner that mimics SNARE complex formation. Mutation of residues in the CALM:SNARE interface inhibits binding in vitro and prevents R-SNARE endocytosis in vivo. Thus, CALM:R-SNARE interactions ensure that R-SNAREs, required for the fusion of endocytic clathrin-coated vesicles with endosomes and also for subsequent postendosomal trafficking, are sorted into endocytic vesicles. CALM's role in directing the endocytosis of small R-SNAREs may provide insight into the association of CALM/PICALM mutations with growth retardation, cognitive defects, and Alzheimer's disease.
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The Molecular Basis for the Endocytosis of Small R-SNAREs by the Clathrin Adaptor CALM.,Miller SE, Sahlender DA, Graham SC, Honing S, Robinson MS, Peden AA, Owen DJ Cell. 2011 Nov 23;147(5):1118-31. PMID:22118466<ref>PMID:22118466</ref>
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The line below this paragraph, containing "STRUCTURE_3zym", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3zym| PDB=3zym | SCENE= }}
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===STRUCTURE OF CALM (PICALM) IN COMPLEX WITH VAMP8===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22118466}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22118466 is the PubMed ID number.
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</StructureSection>
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[[Category: Lk3 transgenic mice]]
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{{ABSTRACT_PUBMED_22118466}}
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==About this Structure==
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[[3zym]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus,_mus_musculus Rattus norvegicus, mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYM OCA].
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==Reference==
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<ref group="xtra">PMID:022118466</ref><references group="xtra"/>
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[[Category: Rattus norvegicus, mus musculus]]
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[[Category: Graham, S C.]]
[[Category: Graham, S C.]]
[[Category: Honing, S.]]
[[Category: Honing, S.]]

Revision as of 08:12, 5 June 2014

STRUCTURE OF CALM (PICALM) IN COMPLEX WITH VAMP8

3zym, resolution 2.03Å

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