3um8

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-	'''Unreleased structure'''	+	[[Image:3um8.jpg|left|200px]]
-	The entry 3um8 is ON HOLD until Paper Publication	+	{{STRUCTURE_3um8| PDB=3um8 | SCENE= }}
-	Authors: Vanichtanankul, J., Chitnumsub, P., Kamchonwongpaisan, S., Yuthavong, Y.	+	===Wild-type Plasmodium falciparum DHFR-TS complexed with cycloguanil and NADPH===
-	Description: Wild-type Plasmodium falciparum DHFR-TS complexed with cycloguanil and NADPH	+	{{ABSTRACT_PUBMED_22526319}}
		+
		+	==About this Structure==
		+	[[3um8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UM8 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022526319</ref><references group="xtra"/>
		+	[[Category: Plasmodium falciparum]]
		+	[[Category: Chitnumsub, P.]]
		+	[[Category: Kamchonwongpaisan, S.]]
		+	[[Category: Vanichtanankul, J.]]
		+	[[Category: Yuthavong, Y.]]
		+	[[Category: Antifolate]]
		+	[[Category: Cycloguanil]]
		+	[[Category: Malarial dhfr-t]]
		+	[[Category: Nadph]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Transferase-inhibitor complex]]

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Revision as of 05:25, 18 July 2012

Template:STRUCTURE 3um8

Wild-type Plasmodium falciparum DHFR-TS complexed with cycloguanil and NADPH

Template:ABSTRACT PUBMED 22526319

About this Structure

3um8 is a 2 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

• Vanichtanankul J, Taweechai S, Uttamapinant C, Chitnumsub P, Vilaivan T, Yuthavong Y, Kamchonwongpaisan S. Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil. Antimicrob Agents Chemother. 2012 Jul;56(7):3928-35. Epub 2012 Apr 23. PMID:22526319 doi:10.1128/AAC.00301-12