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=== The active site tunnel ===
=== The active site tunnel ===
=== The Carnitine binding site===
=== The Carnitine binding site===
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=== THE CoA binding site ===
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=== The CoA binding site ===
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=== THE fatty acid binding site ===
+
=== The fatty acid binding site ===
== Biological function ==
== Biological function ==

Revision as of 11:13, 16 December 2011

The carnitine acetyltransferases (also known as CATs) belong to the family of enzymes known as the carnitine acyltransferases, which also includes carnitine octanoyltransferases (CrOTs) and carnitine palmityltransferase (CPTs). The three known classes of carnitine acyltransferases differ in their acyl group specificity. Carnitine acetyltransferase has a substrate preference for short chain acyl-CoAs whereas carnitine palmityltransferases and carnitine palmityltransferases show preference for long chain acyl-CoAs.They are found in the mitochondrial matrix. Carnitine acetyltransferases are localized in both the outer membrane and the inner membrane.

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Contents

Carnitine acetyltransferase

Structure of Carnitine acetyltransferase

Overall structure

The active site tunnel

The Carnitine binding site

The CoA binding site

The fatty acid binding site

Biological function

Mechanism of Carnitine acetyltranferase

Regulation

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