11gs

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[[Image:11gs.png|left|200px]]
 
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{{STRUCTURE_11gs| PDB=11gs | SCENE= }}
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===Glutathione s-transferase complexed with ethacrynic acid-glutathione conjugate (form ii)===
===Glutathione s-transferase complexed with ethacrynic acid-glutathione conjugate (form ii)===
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{{ABSTRACT_PUBMED_9426214}}
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==Function==
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[[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>
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{{ABSTRACT_PUBMED_9426214}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:009426214</ref><references group="xtra"/>
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<ref group="xtra">PMID:009426214</ref><references group="xtra"/><references/>
[[Category: Glutathione transferase]]
[[Category: Glutathione transferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]

Revision as of 06:28, 10 April 2014

Template:STRUCTURE 11gs

Contents

Glutathione s-transferase complexed with ethacrynic acid-glutathione conjugate (form ii)

Template:ABSTRACT PUBMED 9426214

Function

[GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.[1]

About this Structure

11gs is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Oakley AJ, Lo Bello M, Mazzetti AP, Federici G, Parker MW. The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes. FEBS Lett. 1997 Dec 8;419(1):32-6. PMID:9426214
  1. ↑ Sun KH, Chang KH, Clawson S, Ghosh S, Mirzaei H, Regnier F, Shah K. Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity. J Neurochem. 2011 Sep;118(5):902-14. doi: 10.1111/j.1471-4159.2011.07343.x. Epub , 2011 Jul 8. PMID:21668448 doi:10.1111/j.1471-4159.2011.07343.x

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OCA

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