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13gs
From Proteopedia
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{{STRUCTURE_13gs| PDB=13gs | SCENE= }} | {{STRUCTURE_13gs| PDB=13gs | SCENE= }} | ||
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===GLUTATHIONE S-TRANSFERASE COMPLEXED WITH SULFASALAZINE=== | ===GLUTATHIONE S-TRANSFERASE COMPLEXED WITH SULFASALAZINE=== | ||
| + | {{ABSTRACT_PUBMED_10452896}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.]<ref>PMID:21668448</ref> | |
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==About this Structure== | ==About this Structure== | ||
[[13gs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=13GS OCA]. | [[13gs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=13GS OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Glutathione S-transferase|Glutathione S-transferase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:010452896</ref><references group="xtra"/> | + | <ref group="xtra">PMID:010452896</ref><references group="xtra"/><references/> |
[[Category: Glutathione transferase]] | [[Category: Glutathione transferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 10:26, 21 March 2013
Contents |
GLUTATHIONE S-TRANSFERASE COMPLEXED WITH SULFASALAZINE
Template:ABSTRACT PUBMED 10452896
Function
[GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.][1]
About this Structure
13gs is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Oakley AJ, Lo Bello M, Nuccetelli M, Mazzetti AP, Parker MW. The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site). J Mol Biol. 1999 Aug 27;291(4):913-26. PMID:10452896 doi:10.1006/jmbi.1999.3029
- ↑ Sun KH, Chang KH, Clawson S, Ghosh S, Mirzaei H, Regnier F, Shah K. Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity. J Neurochem. 2011 Sep;118(5):902-14. doi: 10.1111/j.1471-4159.2011.07343.x. Epub , 2011 Jul 8. PMID:21668448 doi:10.1111/j.1471-4159.2011.07343.x
