2j6j
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Glycoprotein G of the vesicular stomatitis virus triggers membrane fusion | + | Glycoprotein G of the vesicular stomatitis virus triggers membrane fusion via a low pH-induced structural rearrangement. Despite the equilibrium between the pre- and postfusion states, the structure of the prefusion form, determined to 3.0 angstrom resolution, shows that the fusogenic transition entails an extensive structural reorganization of G. Comparison with the structure of the postfusion form suggests a pathway for the conformational change. In the prefusion form, G has the shape of a tripod with the fusion loops exposed, which point toward the viral membrane, and with the antigenic sites located at the distal end of the molecule. A large number of G glycoproteins, perhaps organized as in the crystals, act cooperatively to induce membrane merging. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Vesicular stomatitis indiana virus]] | [[Category: Vesicular stomatitis indiana virus]] | ||
[[Category: Bressanelli, S.]] | [[Category: Bressanelli, S.]] | ||
| - | [[Category: Rey, F | + | [[Category: Rey, F A.]] |
[[Category: Roche, S.]] | [[Category: Roche, S.]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
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[[Category: virion protein]] | [[Category: virion protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:00:04 2008'' |
Revision as of 16:00, 21 February 2008
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PREFUSION FORM OF THE VESICULAR STOMATITIS VIRUS GLYCOPROTEIN G ECTODOMAIN
Overview
Glycoprotein G of the vesicular stomatitis virus triggers membrane fusion via a low pH-induced structural rearrangement. Despite the equilibrium between the pre- and postfusion states, the structure of the prefusion form, determined to 3.0 angstrom resolution, shows that the fusogenic transition entails an extensive structural reorganization of G. Comparison with the structure of the postfusion form suggests a pathway for the conformational change. In the prefusion form, G has the shape of a tripod with the fusion loops exposed, which point toward the viral membrane, and with the antigenic sites located at the distal end of the molecule. A large number of G glycoproteins, perhaps organized as in the crystals, act cooperatively to induce membrane merging.
About this Structure
2J6J is a Single protein structure of sequence from Vesicular stomatitis indiana virus with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G., Roche S, Rey FA, Gaudin Y, Bressanelli S, Science. 2007 Feb 9;315(5813):843-8. PMID:17289996
Page seeded by OCA on Thu Feb 21 18:00:04 2008
