3rop
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | [[Image:3rop.jpg|left|200px]] | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_3rop", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_3rop| PDB=3rop | SCENE= }} | {{STRUCTURE_3rop| PDB=3rop | SCENE= }} | ||
| - | |||
===Crystal structure of human CD38 in complex with compound CZ-50b=== | ===Crystal structure of human CD38 in complex with compound CZ-50b=== | ||
| + | {{ABSTRACT_PUBMED_22142305}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
==About this Structure== | ==About this Structure== | ||
[[3rop]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ROP OCA]. | [[3rop]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ROP OCA]. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:022142305</ref><references group="xtra"/> | + | <ref group="xtra">PMID:022142305</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Hao, Q.]] | [[Category: Hao, Q.]] | ||
Revision as of 12:37, 3 July 2013
Contents |
Crystal structure of human CD38 in complex with compound CZ-50b
Template:ABSTRACT PUBMED 22142305
Function
[CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
About this Structure
3rop is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Kwong AK, Chen Z, Zhang H, Leung FP, Lam CM, Ting KY, Zhang L, Hao Q, Zhang LH, Lee HC. Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38. Biochemistry. 2011 Dec 14. PMID:22142305 doi:10.1021/bi201509f
