3ugy

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[[Image:3ugy.png|left|200px]]
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==HBI (F80Y) CO bound==
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<StructureSection load='3ugy' size='340' side='right' caption='[[3ugy]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ugy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UGY FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sdh|3sdh]], [[4sdh|4sdh]], [[3ugz|3ugz]], [[3uh3|3uh3]], [[3uh5|3uh5]], [[3uh6|3uh6]], [[3uh7|3uh7]], [[3uhb|3uhb]], [[3uhc|3uhc]], [[3uhd|3uhd]], [[3uhe|3uhe]], [[3uhg|3uhg]], [[3uhh|3uhh]], [[3uhi|3uhi]], [[3uhk|3uhk]], [[3uhn|3uhn]], [[3uhq|3uhq]], [[3uhr|3uhr]], [[3uhs|3uhs]], [[3uht|3uht]], [[3uhu|3uhu]], [[3uhv|3uhv]], [[3uhw|3uhw]], [[3uhx|3uhx]], [[3uhy|3uhy]], [[3uhz|3uhz]], [[3ui0|3ui0]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ugy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ugy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ugy RCSB], [http://www.ebi.ac.uk/pdbsum/3ugy PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Here we present a meta-analysis of a large collection of static structures of a protein in the Protein Data Bank in order to extract the progression of structural events during protein function. We apply this strategy to the homodimeric hemoglobin HbI from Scapharca inaequivalvis. We derive a simple dynamic model describing how binding of the first ligand in one of the two chemically identical subunits facilitates a second binding event in the other partner subunit. The results of our ultrafast time-resolved crystallographic studies support this model. We demonstrate that HbI functions like a homodimeric mechanical device, such as pliers or scissors. Ligand-induced motion originating in one subunit is transmitted to the other via conserved pivot points, where the E and F' helices from two partner subunits are "bolted" together to form a stable dimer interface permitting slight relative rotation but preventing sliding.
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Cooperative macromolecular device revealed by meta-analysis of static and time-resolved structures.,Ren Z, Srajer V, Knapp JE, Royer WE Jr Proc Natl Acad Sci U S A. 2011 Dec 14. PMID:22171006<ref>PMID:22171006</ref>
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The line below this paragraph, containing "STRUCTURE_3ugy", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3ugy| PDB=3ugy | SCENE= }}
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===HBI (F80Y) CO bound===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
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The line below this paragraph, {{ABSTRACT_PUBMED_22171006}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 22171006 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_22171006}}
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</StructureSection>
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==About this Structure==
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[[3ugy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UGY OCA].
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==Reference==
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<ref group="xtra">PMID:022171006</ref><references group="xtra"/>
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[[Category: Scapharca inaequivalvis]]
[[Category: Scapharca inaequivalvis]]
[[Category: Knapp, J E.]]
[[Category: Knapp, J E.]]

Revision as of 05:39, 5 June 2014

HBI (F80Y) CO bound

3ugy, resolution 2.10Å

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