3qlg

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'''Unreleased structure'''
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[[Image:3qlg.jpg|left|200px]]
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The entry 3qlg is ON HOLD until Feb 02 2013
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{{STRUCTURE_3qlg| PDB=3qlg | SCENE= }}
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Authors: Boubeva, R., Pernot, L., Perozzo, R., Scapozza, L.
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===Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with dasatinib===
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Description: Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with dasatinib
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{{ABSTRACT_PUBMED_17355866}}
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==About this Structure==
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[[3qlg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLG OCA].
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==Reference==
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<ref group="xtra">PMID:017355866</ref><ref group="xtra">PMID:018940662</ref><references group="xtra"/>
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[[Category: Gallus gallus]]
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[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Boubeva, R.]]
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[[Category: Pernot, L.]]
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[[Category: Perozzo, R.]]
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[[Category: Scapozza, L.]]
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[[Category: C-src l317i mutant]]
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[[Category: Dasatinib]]
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[[Category: Transferase]]
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[[Category: Tyrosine kinase]]

Revision as of 06:36, 8 February 2012

Image:3qlg.jpg

Template:STRUCTURE 3qlg

Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with dasatinib

Template:ABSTRACT PUBMED 17355866

About this Structure

3qlg is a 2 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

  • Seeliger MA, Nagar B, Frank F, Cao X, Henderson MN, Kuriyan J. c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty. Structure. 2007 Mar;15(3):299-311. PMID:17355866 doi:10.1016/j.str.2007.01.015
  • Dar AC, Lopez MS, Shokat KM. Small molecule recognition of c-Src via the Imatinib-binding conformation. Chem Biol. 2008 Oct 20;15(10):1015-22. PMID:18940662 doi:10.1016/j.chembiol.2008.09.007

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OCA

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