3qbn

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[[Image:3qbn.jpg|left|200px]]
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==Structure of Human Aurora A in Complex with a diaminopyrimidine==
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<StructureSection load='3qbn' size='340' side='right' caption='[[3qbn]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qbn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QBN FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E9Z:5-CHLORO-N~4~-CYCLOPROPYL-N~2~-[4-(2-METHOXYETHOXY)PHENYL]PYRIMIDINE-2,4-DIAMINE'>E9Z</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qbn RCSB], [http://www.ebi.ac.uk/pdbsum/3qbn PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Infestation of crops by pathogenic fungi has continued to have a major impact by reducing yield and quality, emphasizing the need to identify new targets and develop new agents to improve methods of crop protection. Here we present Aurora kinase from the phytopathogenic fungus Ustilago maydis as a novel target for N-substituted diaminopyrimidines, a class of small-molecule kinase inhibitors. We show that Aurora kinase is essential in U. maydis and that diaminopyrimidines inhibit its activity in vitro. Furthermore, we observed an overall good correlation between in vitro inhibition of Aurora kinase and growth inhibition of diverse fungi in vivo. In vitro inhibition assays with Ustilago and human Aurora kinases indicate that some compounds of the N-substituted diaminopyrimidine class show specificity for the Ustilago enzyme, thus revealing their potential as selective fungicides.
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Identification of Ustilago maydis Aurora kinase as a novel antifungal target.,Tuckmantel S, Greul JN, Janning P, Brockmeyer A, Grutter C, Simard JR, Gutbrod O, Beck ME, Tietjen K, Rauh D, Schreier PH ACS Chem Biol. 2011 Sep 16;6(9):926-33. Epub 2011 Jun 20. PMID:21671622<ref>PMID:21671622</ref>
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The line below this paragraph, containing "STRUCTURE_3qbn", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3qbn| PDB=3qbn | SCENE= }}
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===Structure of Human Aurora A in Complex with a diaminopyrimidine===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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<!--
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*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
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The line below this paragraph, {{ABSTRACT_PUBMED_21671622}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 21671622 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_21671622}}
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</StructureSection>
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==About this Structure==
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[[3qbn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBN OCA].
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==Reference==
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<ref group="xtra">PMID:021671622</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]

Revision as of 05:28, 4 June 2014

Structure of Human Aurora A in Complex with a diaminopyrimidine

3qbn, resolution 3.50Å

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