4aco

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[[Image:4aco.png|left|200px]]
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==Structure of the budding yeast Ndc10 N-terminal domain==
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<StructureSection load='4aco' size='340' side='right' caption='[[4aco]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4aco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ACO FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aco OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aco RCSB], [http://www.ebi.ac.uk/pdbsum/4aco PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have solved the X-ray structure of the amino-terminal half of the yeast kinetochore protein Ndc10 at 1.8 Angstrom resolution. This essential protein is a key constituent of the budding yeast centromere, and is essential for the recruitment of the centromeric nucleosome and establishment of the kinetochore. The fold of the protein shows unexpected similarities to the tyrosine recombinase/lambda-integrase family of proteins, most notably Cre, with some variation in the relative position of the sub-domains. This finding offers new insights into kinetochore evolution and the adaptation of a well-studied protein fold to a novel role. By comparison to tyrosine recombinases, and mutagenesis studies, we have been able to define some of the key DNA-binding motifs.
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The structure of the yeast kinetochore Ndc10 DNA-binding domain reveals an unexpected evolutionary relationship to tyrosine recombinases.,Perriches T, Singleton MR J Biol Chem. 2012 Jan 3. PMID:22215672<ref>PMID:22215672</ref>
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The line below this paragraph, containing "STRUCTURE_4aco", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_4aco| PDB=4aco | SCENE= }}
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===Structure of the budding yeast Ndc10 N-terminal domain===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22215672}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22215672 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22215672}}
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==About this Structure==
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[[4aco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACO OCA].
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==Reference==
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<ref group="xtra">PMID:022215672</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Perriches, T.]]
[[Category: Perriches, T.]]
[[Category: Singleton, M R.]]
[[Category: Singleton, M R.]]
[[Category: Dna binding protein]]
[[Category: Dna binding protein]]

Revision as of 08:29, 5 June 2014

Structure of the budding yeast Ndc10 N-terminal domain

4aco, resolution 1.89Å

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OCA

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