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4d83

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'''Unreleased structure'''
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[[Image:4d83.jpg|left|200px]]
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The entry 4d83 is ON HOLD until Paper Publication
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{{STRUCTURE_4d83| PDB=4d83 | SCENE= }}
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Authors: Rondeau, J.M., Bourgier, E.
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===Crystal Structure of Human Beta Secretase in Complex with NVP-BUR436, derived from a co-crystallization experiment===
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Description: Crystal Structure of Human Beta Secretase in Complex with NVP-BUR436, derived from a co-crystallization experiment
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{{ABSTRACT_PUBMED_22380629}}
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==About this Structure==
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[[4d83]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D83 OCA].
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==Reference==
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<ref group="xtra">PMID:021388807</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Memapsin 2]]
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[[Category: Bourgier, E.]]
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[[Category: Rondeau, J M.]]
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[[Category: Alzheimer's disease]]
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[[Category: Aspartic proteinase]]
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[[Category: Bace1]]
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[[Category: Beta-secretase]]
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[[Category: Enzyme inhibitor complex]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Memapsin2]]
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[[Category: Structure-based drug design]]

Revision as of 09:26, 21 November 2012

Image:4d83.jpg

Template:STRUCTURE 4d83

Crystal Structure of Human Beta Secretase in Complex with NVP-BUR436, derived from a co-crystallization experiment

Template:ABSTRACT PUBMED 22380629

About this Structure

4d83 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Rueeger H, Rondeau JM, McCarthy C, Mobitz H, Tintelnot-Blomley M, Neumann U, Desrayaud S. Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1942-7. Epub 2011 Feb 15. PMID:21388807 doi:10.1016/j.bmcl.2011.02.038

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OCA

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