Saposin
From Proteopedia
(Difference between revisions)
| Line 13: | Line 13: | ||
===Saposin B=== | ===Saposin B=== | ||
| - | [[1n69]] – hSapB | + | [[1n69]] – hSapB + lipid |
===Saposin C=== | ===Saposin C=== | ||
Revision as of 13:17, 30 January 2012
Saposin (Sap) is a small protein which functions as activator of lipid-degrading enzymes. They act by isolating the lipid substrate from the membrane. Sap is synthesized as a precursor – prosaposin – which contain 4 SapB active domains and 2 SapA domains which are cleaved off. For more details see Molecular Playground/Saposin C.
3D Structures of Saposin
Saposin A
2dob – hSapA residues 60-140 – human
Saposin B
1n69 – hSapB + lipid
Saposin C
1m12, 1sn6 – hSapC – NMR
2gtg, 2qyp, 2z9a – hSapC residues 311-391
Saposin D
3bqp, 3bqq, 2r1q, 2rb3 - hSapD residues 405-484
2r0r - hSapD residues 407-484 (mutant)
