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3tyv

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Revision as of 05:42, 8 February 2012

Image:3tyv.png

Template:STRUCTURE 3tyv

SAR development and discovery of potent indole-based inhibitors of the hepatitis C virus NS5B polymerase

Template:ABSTRACT PUBMED 22148957

About this Structure

3tyv is a 2 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

  • Chen KX, Vibulbhan B, Yang W, Sannigrahi M, Velazquez F, Chan TY, Venkatraman S, Anilkumar GN, Zeng Q, Bennet F, Jiang Y, Lesburg CA, Duca J, Pinto P, Gavalas S, Huang Y, Wu W, Selyutin O, Agrawal S, Feld B, Huang HC, Li C, Cheng KC, Shih NY, Kozlowski JA, Rosenblum SB, Njoroge FG. Structure-Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase. J Med Chem. 2012 Jan 26;55(2):754-65. Epub 2012 Jan 6. PMID:22148957 doi:10.1021/jm201258k

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OCA

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