3u4s

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Revision as of 06:54, 22 February 2012

Template:STRUCTURE 3u4s

Histone Lysine demethylase JMJD2A in complex with T11C peptide substrate crosslinked to N-oxalyl-D-cysteine

Template:ABSTRACT PUBMED 22241642

About this Structure

3u4s is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Woon EC, Tumber A, Kawamura A, Hillringhaus L, Ge W, Rose NR, Ma JH, Chan MC, Walport LJ, Che KH, Ng SS, Marsden BD, Oppermann U, McDonough MA, Schofield CJ. Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases. Angew Chem Int Ed Engl. 2012 Feb 13;51(7):1631-4. doi:, 10.1002/anie.201107833. Epub 2012 Jan 12. PMID:22241642 doi:10.1002/anie.201107833