2onh
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The crystal structure of (4S)-limonene synthase from Mentha spic ata, a | + | The crystal structure of (4S)-limonene synthase from Mentha spic ata, a metal ion-dependent monoterpene cyclase that catalyzes the coupled isomerization and cyclization of geranyl diphosphate, is reported at 2.7-A; resolution in two forms liganded to the substrate and intermediate analogs, 2-fluorogeranyl diphosphate and 2-fluorolinalyl diphosphate, respectively. The implications of these findings are described for domain interactions in the homodimer and for changes in diphosphate-metal ion coordination and substrate binding conformation in the course of the multistep reaction. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Croteau, R.]] | [[Category: Croteau, R.]] | ||
| - | [[Category: Hyatt, D | + | [[Category: Hyatt, D C.]] |
[[Category: Kang, C.]] | [[Category: Kang, C.]] | ||
[[Category: Youn, B.]] | [[Category: Youn, B.]] | ||
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[[Category: monoterpene synthase]] | [[Category: monoterpene synthase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:20:30 2008'' |
Revision as of 16:20, 21 February 2008
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Crystal Structure of of limonene synthase with 2-fluorolinalyl diphosphate(FLPP)
Overview
The crystal structure of (4S)-limonene synthase from Mentha spic ata, a metal ion-dependent monoterpene cyclase that catalyzes the coupled isomerization and cyclization of geranyl diphosphate, is reported at 2.7-A; resolution in two forms liganded to the substrate and intermediate analogs, 2-fluorogeranyl diphosphate and 2-fluorolinalyl diphosphate, respectively. The implications of these findings are described for domain interactions in the homodimer and for changes in diphosphate-metal ion coordination and substrate binding conformation in the course of the multistep reaction.
About this Structure
2ONH is a Single protein structure of sequence from Mentha spicata with , and as ligands. Known structural/functional Sites: , , , , , , , and . Full crystallographic information is available from OCA.
Reference
Structure of limonene synthase, a simple model for terpenoid cyclase catalysis., Hyatt DC, Youn B, Zhao Y, Santhamma B, Coates RM, Croteau RB, Kang C, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5360-5. Epub 2007 Mar 19. PMID:17372193
Page seeded by OCA on Thu Feb 21 18:20:30 2008
