1nav

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[[Image:1nav.png|left|200px]]
 
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{{STRUCTURE_1nav| PDB=1nav | SCENE= }}
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===Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1===
===Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1===
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{{ABSTRACT_PUBMED_12699376}}
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==Disease==
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[[http://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN]] Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:[http://omim.org/entry/614450 614450]]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.<ref>PMID:22168587</ref>
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==Function==
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[[http://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN]] Nuclear hormone receptor. High affinity receptor for triiodothyronine.
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(as it appears on PubMed at http://www.pubmed.gov), where 12699376 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12699376}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:012699376</ref><references group="xtra"/>
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<ref group="xtra">PMID:012699376</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bladh, L G.]]
[[Category: Bladh, L G.]]

Revision as of 06:14, 25 March 2013

Template:STRUCTURE 1nav

Contents

Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1

Template:ABSTRACT PUBMED 12699376

Disease

[THA_HUMAN] Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:614450]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.[1]

Function

[THA_HUMAN] Nuclear hormone receptor. High affinity receptor for triiodothyronine.

About this Structure

1nav is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Ye L, Li YL, Mellstrom K, Mellin C, Bladh LG, Koehler K, Garg N, Garcia Collazo AM, Litten C, Husman B, Persson K, Ljunggren J, Grover G, Sleph PG, George R, Malm J. Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1. J Med Chem. 2003 Apr 24;46(9):1580-8. PMID:12699376 doi:http://dx.doi.org/10.1021/jm021080f
  1. ↑ Bochukova E, Schoenmakers N, Agostini M, Schoenmakers E, Rajanayagam O, Keogh JM, Henning E, Reinemund J, Gevers E, Sarri M, Downes K, Offiah A, Albanese A, Halsall D, Schwabe JW, Bain M, Lindley K, Muntoni F, Vargha-Khadem F, Dattani M, Farooqi IS, Gurnell M, Chatterjee K. A mutation in the thyroid hormone receptor alpha gene. N Engl J Med. 2012 Jan 19;366(3):243-9. doi: 10.1056/NEJMoa1110296. Epub 2011 Dec, 14. PMID:22168587 doi:10.1056/NEJMoa1110296

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OCA

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