2idy
From Proteopedia
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==Overview== | ==Overview== | ||
| - | This paper describes the structure determination of nsp3a, the N-terminal | + | This paper describes the structure determination of nsp3a, the N-terminal domain of the severe acute respiratory syndrome coronavirus (SARS-CoV) nonstructural protein 3. nsp3a exhibits a ubiquitin-like globular fold of residues 1 to 112 and a flexibly extended glutamic acid-rich domain of residues 113 to 183. In addition to the four beta-strands and two alpha-helices that are common to ubiquitin-like folds, the globular domain of nsp3a contains two short helices representing a feature that has not previously been observed in these proteins. Nuclear magnetic resonance chemical shift perturbations showed that these unique structural elements are involved in interactions with single-stranded RNA. Structural similarities with proteins involved in various cell-signaling pathways indicate possible roles of nsp3a in viral infection and persistence. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Sars coronavirus]] | [[Category: Sars coronavirus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Almeida, M | + | [[Category: Almeida, M S.]] |
[[Category: Herrmann, T.]] | [[Category: Herrmann, T.]] | ||
[[Category: Horst, R.]] | [[Category: Horst, R.]] | ||
| - | [[Category: JCSG, Joint | + | [[Category: JCSG, Joint Center for Structural Genomics.]] |
| - | [[Category: Johnson, M | + | [[Category: Johnson, M A.]] |
[[Category: Joseph, J.]] | [[Category: Joseph, J.]] | ||
[[Category: Kuhn, P.]] | [[Category: Kuhn, P.]] | ||
[[Category: Saikatendu, K.]] | [[Category: Saikatendu, K.]] | ||
[[Category: Serrano, P.]] | [[Category: Serrano, P.]] | ||
| - | [[Category: Stevens, R | + | [[Category: Stevens, R C.]] |
[[Category: Subramanian, V.]] | [[Category: Subramanian, V.]] | ||
[[Category: Wuthrich, K.]] | [[Category: Wuthrich, K.]] | ||
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[[Category: viral protein]] | [[Category: viral protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:51:38 2008'' |
Revision as of 15:51, 21 February 2008
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NMR Structure of the SARS-CoV non-structural protein nsp3a
Overview
This paper describes the structure determination of nsp3a, the N-terminal domain of the severe acute respiratory syndrome coronavirus (SARS-CoV) nonstructural protein 3. nsp3a exhibits a ubiquitin-like globular fold of residues 1 to 112 and a flexibly extended glutamic acid-rich domain of residues 113 to 183. In addition to the four beta-strands and two alpha-helices that are common to ubiquitin-like folds, the globular domain of nsp3a contains two short helices representing a feature that has not previously been observed in these proteins. Nuclear magnetic resonance chemical shift perturbations showed that these unique structural elements are involved in interactions with single-stranded RNA. Structural similarities with proteins involved in various cell-signaling pathways indicate possible roles of nsp3a in viral infection and persistence.
About this Structure
2IDY is a Single protein structure of sequence from Sars coronavirus. Full crystallographic information is available from OCA.
Reference
Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus., Serrano P, Johnson MA, Almeida MS, Horst R, Herrmann T, Joseph JS, Neuman BW, Subramanian V, Saikatendu KS, Buchmeier MJ, Stevens RC, Kuhn P, Wuthrich K, J Virol. 2007 Nov;81(21):12049-60. Epub 2007 Aug 29. PMID:17728234
Page seeded by OCA on Thu Feb 21 17:51:38 2008
Categories: Sars coronavirus | Single protein | Almeida, M S. | Herrmann, T. | Horst, R. | JCSG, Joint Center for Structural Genomics. | Johnson, M A. | Joseph, J. | Kuhn, P. | Saikatendu, K. | Serrano, P. | Stevens, R C. | Subramanian, V. | Wuthrich, K. | Jcsg | Joint center for structural genomics | Protein structure initiative | Psi-2 | Sars coronavirus nmr nsp3a | Structural genomics | Viral protein
