This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3rin
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | [[ | + | ==p38 kinase crystal structure in complex with small molecule inhibitor== |
| + | <StructureSection load='3rin' size='340' side='right' caption='[[3rin]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3rin]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RIN FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I2O:N-CYCLOPROPYL-4-METHYL-3-(2-OXO-1,2-DIHYDROSPIRO[CYCLOPENTANE-1,3-INDOL]-6-YL)BENZAMIDE'>I2O</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rin OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rin RCSB], [http://www.ebi.ac.uk/pdbsum/3rin PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The use of structure-based design and molecular modeling led to the discovery of indolin-2-one derivatives as potent and selective p38alpha inhibitors. The predicted binding mode was confirmed by X-ray crystallography. | ||
| - | + | Indolin-2-one p38alpha inhibitors I: design, profiling and crystallographic binding mode.,Eastwood P, Gonzalez J, Gomez E, Vidal B, Caturla F, Roca R, Balague C, Orellana A, Dominguez M Bioorg Med Chem Lett. 2011 Jul 15;21(14):4130-3. Epub 2011 Jun 6. PMID:21696951<ref>PMID:21696951</ref> | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| - | + | ==See Also== | |
| - | + | *[[Mitogen-activated protein kinase|Mitogen-activated protein kinase]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | == | + | |
| - | [[ | + | |
| - | + | ||
| - | == | + | |
| - | < | + | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mitogen-activated protein kinase]] | [[Category: Mitogen-activated protein kinase]] | ||
Revision as of 04:47, 5 June 2014
p38 kinase crystal structure in complex with small molecule inhibitor
| |||||||||||
