Sandbox Reserved 425

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	===Introduction===		===Introduction===
-	<scene name='Sandbox_Reserved_425/Test2/1'>test</scene>	+	- COMT responsible for degradation of catchol neurotransmitters including DA
-	<scene name='Sandbox_Reserved_425/Test_2/1'>test 2</scene>	+	- PD symptoms result from low levels of DA
		+	- inhibiting COMT has potential to treat PD in conjunction with L-DOPA (a DA precursor currently used to treat PD) by increasing the bioavailability and stability of L-DOPA
		+	- 4PCM is a COMT inhibitor being studied to better understand inhibitor interactions with COMT in order to develop better inhibitors
		+	- carbonyl oxygen interacts with Trp143
	===Overall Structure===		===Overall Structure===

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Revision as of 05:10, 5 March 2012

spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439.

Contents 1 YourMacromolecule 1.1 Introduction 1.2 Overall Structure 1.3 Binding Interactions 1.4 Additional Features 1.5 Credits 1.6 References

YourMacromolecule

Introduction

- COMT responsible for degradation of catchol neurotransmitters including DA - PD symptoms result from low levels of DA - inhibiting COMT has potential to treat PD in conjunction with L-DOPA (a DA precursor currently used to treat PD) by increasing the bioavailability and stability of L-DOPA - 4PCM is a COMT inhibitor being studied to better understand inhibitor interactions with COMT in order to develop better inhibitors

       - carbonyl oxygen interacts with Trp143

Overall Structure

Biological Unit with DNA - green scene

Polar/nonpolar regions green scene

Secondary Structure green scene

-alpha helixes-phi and psi angles in one helix-how many-location

-beta sheets-kinds-how many-locations

Ligand structure KOM-AC3, MG-AC1, SAM-AC2 ball and stick green scene

Binding Interactions

Additional Features

Credits

Introduction - Jessica Royal

Overall Structure - Stephanie Bristol

Drug Binding Site - Emily Brackett

Additional Features - Anh Huynh

References