Journal:JMB:2
From Proteopedia
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and I74 in particular, comprises part of PON1's active-site wall. <scene name='Journal:JMB:2/2d/2'>(D)</scene> Interactions of 2HQ with | and I74 in particular, comprises part of PON1's active-site wall. <scene name='Journal:JMB:2/2d/2'>(D)</scene> Interactions of 2HQ with | ||
active-site residues (interactions with the catalytic Ca2+ are highlighted in red). | active-site residues (interactions with the catalytic Ca2+ are highlighted in red). | ||
| - | + | <hr/> | |
| + | <b>Additional Structures</b> | ||
| + | <Structure load='Workbench_test3.pdb' size='500' frame='true' align='left' caption='Newly solved structure of rePON1 at pH 6.5' scene='Insert optional scene name here' /><br> | ||
| + | <Structure load='1V04' size='500' frame='true' align='left' caption='Previously solved structure of rePON1 at pH 4.5' scene='Insert optional scene name here' /> | ||
<references/> | <references/> | ||
__NOEDITSECTION__ | __NOEDITSECTION__ | ||
Revision as of 17:53, 6 March 2012
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Catalytic versatility and backups in enzyme active sites: The case of serum paraoxanase 1
Moshe Ben-David, Mikael Elias, Jean-Jacques Filippi, Elisabet Dunach, Israel Silman, Joel Sussman and Dan Tawfik, PhD[1]
Molecular Tour
Figure 2. Structural details of the 2HQ/rePON1 complex at pH 6.5; 2HQ and the
structured active-site loop in the rePON1-2HQ complex structure. Overlay of the phosphate ion in the apo rePON1 at pH 6.5 and of 2HQ
in the rePON1-2HQ complex. The first segment of the active-site loop, and residues Y71
and I74 in particular, comprises part of PON1's active-site wall. Interactions of 2HQ with
active-site residues (interactions with the catalytic Ca2+ are highlighted in red).
Additional Structures
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- ↑ none yet
