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Ketohexokinase
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| - | {{STRUCTURE_3nbv| PDB=3nbv | SIZE=400| SCENE= |right|CAPTION=Ketohexokinase complex with fructose and AMPPNP [[3nbv]] }} | + | {{STRUCTURE_3nbv| PDB=3nbv | SIZE=400| SCENE= |right|CAPTION=Ketohexokinase dimer complex with fructose and AMPPNP [[3nbv]] }} |
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Revision as of 10:57, 5 November 2012
Ketohexokinase (KHK) also known as hepatic fructokinase catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in the liver. The HKH gene is spliced to HKH-A and the more active HKH-C. HKH deficiency causes the essential fructosuria disorder. KHK acts in the first step of fructose metabolism.
3D structuresm of ketohexokinase
2hlz, 2hqq, 3b3l – hKHK – human
2hw1, 3nbv – hKHK + AMPPNP + fructose
3nbw – hKHK + pyrazole derivative
3nc2, 3nc9, 3nca, 3ro4, 3q92, 3qa2, 3qai – hKHK + inhibitor
