Journal:JMB:2
From Proteopedia
| Line 6: | Line 6: | ||
Old rePON1 at pH 4.5<scene name='Journal:JMB:2/New_no_hq/3'>TextToBeDisplayed</scene> | Old rePON1 at pH 4.5<scene name='Journal:JMB:2/New_no_hq/3'>TextToBeDisplayed</scene> | ||
| - | New rePON1 at pH 6.4 | + | New rePON1 at pH 6.4<scene name='Journal:JMB:2/First/2'>TextToBeDisplayed</scene> |
Figure 2. Structural details of the 2HQ/rePON1 complex at pH 6.5; <scene name='Journal:JMB:2/2a/4'> (A)</scene> 2HQ and the | Figure 2. Structural details of the 2HQ/rePON1 complex at pH 6.5; <scene name='Journal:JMB:2/2a/4'> (A)</scene> 2HQ and the | ||
| Line 13: | Line 13: | ||
and I74 in particular, comprises part of PON1's active-site wall. <scene name='Journal:JMB:2/2d/2'>(D)</scene> Interactions of 2HQ with | and I74 in particular, comprises part of PON1's active-site wall. <scene name='Journal:JMB:2/2d/2'>(D)</scene> Interactions of 2HQ with | ||
active-site residues (interactions with the catalytic Ca2+ are highlighted in red). | active-site residues (interactions with the catalytic Ca2+ are highlighted in red). | ||
| - | |||
| - | <hr/> | ||
| - | <b>Crystal Structures submitted to PDB database</b><br> | ||
| - | |||
| - | <table width='1000' align='center' cellpadding='2'><td rowspan='2'> </td><td bgcolor='#eeeeee'> | ||
| - | <center>'''New rePON1 with 2HQ''' </center><applet load='Workbench_test2.pdb' size='325' frame='true' align='left' scene='Journal:JMB:2/Opening/1' target='0' /></td><td bgcolor='#eeeeee'> | ||
| - | <center>'''New rePON1 at pH of 6.5''' </center><applet load='Workbench_test3.pdb' size='325' frame='true' align='center' scene='Journal:JMB:2/New_no_hq/2' target='0' /></td><td bgcolor='#eeeeee'> | ||
| - | <center>'''Old rePON1 at pH of 4.5''' </center><applet load='1V04' size='325' frame='true' align='right' scene='Journal:JMB:2/First/1' target='0' /></td><td bgcolor='#eeeeee'> | ||
<references/> | <references/> | ||
__NOEDITSECTION__ | __NOEDITSECTION__ | ||
Revision as of 12:03, 7 March 2012
|
Catalytic versatility and backups in enzyme active sites: The case of serum paraoxanase 1
Moshe Ben-David, Mikael Elias, Jean-Jacques Filippi, Elisabet Dunach, Israel Silman, Joel Sussman and Dan Tawfik, PhD[1]
Molecular Tour
Old rePON1 at pH 4.5 New rePON1 at pH 6.4
Figure 2. Structural details of the 2HQ/rePON1 complex at pH 6.5; 2HQ and the structured active-site loop in the rePON1-2HQ complex structure. Overlay of the phosphate ion in the apo rePON1 at pH 6.5 and of 2HQ in the rePON1-2HQ complex. The first segment of the active-site loop, and residues Y71 and I74 in particular, comprises part of PON1's active-site wall. Interactions of 2HQ with active-site residues (interactions with the catalytic Ca2+ are highlighted in red).
- ↑ none yet
