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Journal:JMB:2
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structured active-site loop in the rePON1-2HQ complex structure. <scene name='Journal:JMB:2/2b/1'>(B)</scene> Overlay of the phosphate ion in the apo rePON1 at pH 6.5 and of 2HQ | structured active-site loop in the rePON1-2HQ complex structure. <scene name='Journal:JMB:2/2b/1'>(B)</scene> Overlay of the phosphate ion in the apo rePON1 at pH 6.5 and of 2HQ | ||
in the rePON1-2HQ complex. <scene name='Journal:JMB:2/2c/1'>(C)</scene> The first segment of the active-site loop, and residues Y71 | in the rePON1-2HQ complex. <scene name='Journal:JMB:2/2c/1'>(C)</scene> The first segment of the active-site loop, and residues Y71 | ||
| - | and I74 in particular, comprises part of PON1's active-site wall. <scene name='Journal:JMB:2/2d/ | + | and I74 in particular, comprises part of PON1's active-site wall. <scene name='Journal:JMB:2/2d/3'>(D)</scene> Interactions of 2HQ with |
active-site residues (interactions with the catalytic Ca2+ are highlighted in red). | active-site residues (interactions with the catalytic Ca2+ are highlighted in red). | ||
<references/> | <references/> | ||
__NOEDITSECTION__ | __NOEDITSECTION__ | ||
Revision as of 12:23, 7 March 2012
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Catalytic versatility and backups in enzyme active sites: The case of serum paraoxanase 1
Moshe Ben-David, Mikael Elias, Jean-Jacques Filippi, Elisabet Dunach, Israel Silman, Joel Sussman and Dan Tawfik, PhD[1]
Molecular Tour
New 2HQ/rePON1 complex at pH 6.5
New rePON1 at pH 6.5
Old rePON1 at pH 4.5
Figure 2. Structural details of the 2HQ/rePON1 complex at pH 6.5; 2HQ and the structured active-site loop in the rePON1-2HQ complex structure. Overlay of the phosphate ion in the apo rePON1 at pH 6.5 and of 2HQ in the rePON1-2HQ complex. The first segment of the active-site loop, and residues Y71 and I74 in particular, comprises part of PON1's active-site wall. Interactions of 2HQ with active-site residues (interactions with the catalytic Ca2+ are highlighted in red).
- ↑ none yet
