3vem

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[[Image:3vem.jpg|left|200px]]
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==Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1==
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<StructureSection load='3vem' size='340' side='right' caption='[[3vem]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3vem]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VEM FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MOM1, MOM, At1g08060, T6D22.14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vem OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vem RCSB], [http://www.ebi.ac.uk/pdbsum/3vem PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Shifts between epigenetic states of transcriptional activity are typically correlated with changes in epigenetic marks. However, exceptions to this rule suggest the existence of additional, as yet uncharacterized, layers of epigenetic regulation. MOM1, a protein of 2,001 amino acids that acts as a transcriptional silencer, represents such an exception. Here we define the 82 amino acid domain called CMM2 (Conserved MOM1 Motif 2) as a minimal MOM1 fragment capable of transcriptional regulation. As determined by X-ray crystallography, this motif folds into an unusual hendecad-based coiled-coil. Structure-based mutagenesis followed by transgenic complementation tests in plants demonstrate that CMM2 and its dimerization are effective for transcriptional suppression at chromosomal loci co-regulated by MOM1 and the siRNA pathway but not at loci controlled by MOM1 in an siRNA-independent fashion. These results reveal a surprising separation of epigenetic activities that enable the single, large MOM1 protein to coordinate cooperating mechanisms of epigenetic regulation.
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Structural Basis of Transcriptional Gene Silencing Mediated by Arabidopsis MOM1.,Nishimura T, Molinard G, Petty TJ, Broger L, Gabus C, Halazonetis TD, Thore S, Paszkowski J PLoS Genet. 2012 Feb;8(2):e1002484. Epub 2012 Feb 9. PMID:22346760<ref>PMID:22346760</ref>
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The line below this paragraph, containing "STRUCTURE_3vem", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3vem| PDB=3vem | SCENE= }}
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===Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22346760}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22346760 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22346760}}
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==About this Structure==
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[[3vem]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEM OCA].
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==Reference==
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<ref group="xtra">PMID:022346760</ref><references group="xtra"/>
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[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Halazonetis, T.]]
[[Category: Halazonetis, T.]]

Revision as of 07:12, 5 June 2014

Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1

3vem, resolution 3.20Å

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