Carnitine palmitoyltransferase
From Proteopedia
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[[2rcu]] – rCPT II + substrate analog<br /> | [[2rcu]] – rCPT II + substrate analog<br /> | ||
[[2le3]] – CPT I residues 1-42 – human - NMR | [[2le3]] – CPT I residues 1-42 – human - NMR | ||
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Revision as of 10:52, 12 March 2012
Carnitine palmitoyltransferase (CPT I and CPT II) are involved in the transport of long-chain fatty acids into the mitochondria where they are oxidized. Fatty acids form a conjugate with CoA before being oxidized in the mitochondria. However, the CoA-long-chain fatty acid conjugates can not diffuse into the mitochondria. CPT I is a membrane protein which substitutes the CoA in the long-chain fatty acids by carnitine. After entering the mitochondria, CPT II exchanges the carnitine by CoA, enabling the oxidation of the long-chain fatty acids. CPT I is important in fatty acid disorders like diabetes.
3D structures of carnitine palmitoyltransferase
2h4t, 2fyo, 2deb – rCPT II – rat
2fw3 - rCPT II + antidiabetic drug
2rcu – rCPT II + substrate analog
2le3 – CPT I residues 1-42 – human - NMR
