3hpx

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[[Image:3hpx.png|left|200px]]
 
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{{STRUCTURE_3hpx| PDB=3hpx | SCENE= }}
{{STRUCTURE_3hpx| PDB=3hpx | SCENE= }}
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===Crystal structure of Mycobacterium tuberculosis LeuA active site domain 1-425 (truncation mutant delta:426-644)===
===Crystal structure of Mycobacterium tuberculosis LeuA active site domain 1-425 (truncation mutant delta:426-644)===
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{{ABSTRACT_PUBMED_22352945}}
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==Function==
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[[http://www.uniprot.org/uniprot/LEU1_MYCTU LEU1_MYCTU]] Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity).
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{{ABSTRACT_PUBMED_22352945}}
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==About this Structure==
==About this Structure==
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[[3hpx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPX OCA].
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[[3hpx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPX OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:022352945</ref><references group="xtra"/>
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<ref group="xtra">PMID:022352945</ref><references group="xtra"/><references/>
[[Category: 2-isopropylmalate synthase]]
[[Category: 2-isopropylmalate synthase]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Mycobacterium tuberculosis h37rv]]
[[Category: Baker, E N.]]
[[Category: Baker, E N.]]
[[Category: Koon, N.]]
[[Category: Koon, N.]]

Revision as of 07:34, 20 June 2013

Template:STRUCTURE 3hpx

Contents

Crystal structure of Mycobacterium tuberculosis LeuA active site domain 1-425 (truncation mutant delta:426-644)

Template:ABSTRACT PUBMED 22352945

Function

[LEU1_MYCTU] Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity).

About this Structure

3hpx is a 2 chain structure with sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.

Reference

  • Huisman FH, Koon N, Bulloch EM, Baker HM, Baker EN, Squire CJ, Parker EJ. Removal of the C-Terminal Regulatory Domain of alpha-Isopropylmalate Synthase Disrupts Functional Substrate Binding. Biochemistry. 2012 Mar 6. PMID:22352945 doi:10.1021/bi201717j

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OCA

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