4dsu

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'''Unreleased structure'''
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[[Image:4dsu.jpg|left|200px]]
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The entry 4dsu is ON HOLD until Paper Publication
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{{STRUCTURE_4dsu| PDB=4dsu | SCENE= }}
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Authors: Oh, A., Maurer, T., Garrenton, L.S., Pitts, K., Anderson, D.J., Skelton, N.J., Fauber, B.P., Pan, B., Malek, S., Stokoe, D., Ludlam, M., Bowman, K.K., Wu, J., Giannetti, A.M., Starovasnik, M.A., Mellman, I., Jackson, P.K., Ruldolph, J., Fang, G., Wang, W.
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===Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity===
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Description: Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
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{{ABSTRACT_PUBMED_22431598}}
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==About this Structure==
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[[4dsu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DSU OCA].
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==Reference==
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<ref group="xtra">PMID:022431598</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Anderson, D J.]]
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[[Category: Bowman, K K.]]
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[[Category: Fang, G.]]
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[[Category: Fauber, B P.]]
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[[Category: Garrenton, L S.]]
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[[Category: Giannetti, A M.]]
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[[Category: Jackson, P K.]]
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[[Category: Ludlam, M.]]
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[[Category: Malek, S.]]
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[[Category: Maurer, T.]]
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[[Category: Mellman, I.]]
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[[Category: Oh, A.]]
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[[Category: Pan, B.]]
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[[Category: Pitts, K.]]
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[[Category: Ruldolph, J.]]
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[[Category: Skelton, N J.]]
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[[Category: Starovasnik, M A.]]
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[[Category: Stokoe, D.]]
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[[Category: Wang, W.]]
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[[Category: Wu, J.]]
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[[Category: Hydrolase]]
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[[Category: Signaling]]
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[[Category: Small g-protein]]

Revision as of 06:05, 4 April 2012

Image:4dsu.jpg

Template:STRUCTURE 4dsu

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Template:ABSTRACT PUBMED 22431598

About this Structure

4dsu is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Maurer T, Garrenton LS, Oh A, Pitts K, Anderson DJ, Skelton NJ, Fauber BP, Pan B, Malek S, Stokoe D, Ludlam MJ, Bowman KK, Wu J, Giannetti AM, Starovasnik MA, Mellman I, Jackson PK, Rudolph J, Wang W, Fang G. Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc Natl Acad Sci U S A. 2012 Mar 19. PMID:22431598 doi:10.1073/pnas.1116510109

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OCA

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