3ay5
From Proteopedia
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{{STRUCTURE_3ay5| PDB=3ay5 | SCENE= }} | {{STRUCTURE_3ay5| PDB=3ay5 | SCENE= }} | ||
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===Crystal structure of HHM (human homologue of murine maternal Id-like molecule)=== | ===Crystal structure of HHM (human homologue of murine maternal Id-like molecule)=== | ||
| + | {{ABSTRACT_PUBMED_22453338}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/CCDB1_HUMAN CCDB1_HUMAN]] May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.<ref>PMID:10801854</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3ay5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AY5 OCA]. | [[3ay5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AY5 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022453338</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ishitani, R.]] | [[Category: Ishitani, R.]] | ||
Revision as of 15:36, 19 June 2013
Contents |
Crystal structure of HHM (human homologue of murine maternal Id-like molecule)
Template:ABSTRACT PUBMED 22453338
Function
[CCDB1_HUMAN] May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.[1]
About this Structure
3ay5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Ishii R, Isogaya K, Seto A, Koinuma D, Watanabe Y, Arisaka F, Yaguchi S, Ikushima H, Dohmae N, Miyazono K, Miyazawa K, Ishitani R, Nureki O. Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition. EMBO J. 2012 Mar 27;31(11):2541-52. doi: 10.1038/emboj.2012.77. PMID:22453338 doi:10.1038/emboj.2012.77
- ↑ Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M. GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity. J Biol Chem. 2000 Jul 7;275(27):20942-8. PMID:10801854 doi:10.1074/jbc.M002598200
