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Hirudin

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== 3D Structures of Hirudin ==
== 3D Structures of Hirudin ==
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''Update November 2011''
+
''Update June 2012''
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+
=== Hirudin ===
=== Hirudin ===
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[[1hic]], [[2hir]], [[4hir]], [[5hir]], [[6hir]] – Hir – NMR<br />
[[1hic]], [[2hir]], [[4hir]], [[5hir]], [[6hir]] – Hir – NMR<br />
[[2joo]] - Hir – NMR<br />
[[2joo]] - Hir – NMR<br />
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=== Hirudin + Thrombin light and heavy chains ===
=== Hirudin + Thrombin light and heavy chains ===
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[[1hrt]], [[3htc]], [[4htc]] - Hir +hThr L&H chains<br />
[[1hrt]], [[3htc]], [[4htc]] - Hir +hThr L&H chains<br />
[[3da9]] - Hir peptide+hThr L&H chains<br />
[[3da9]] - Hir peptide+hThr L&H chains<br />
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+
[[3qtv]], [[3qwc]], [[3qx5]] - Hir peptide + hThr L&H chains + pyridine derivative<br />
 +
[[3rlw]], [[3rly]], [[3rm0]], [[3rm2]], [[3rml]], [[3rmm]], [[3rmn]], [[3rmo]] - Hir peptide + hThr L&H chains + inhibitor<br />
 +
[[3qto]] - Hir +hThr L&H chains + pyridine derivative
=== Hirugen + Thrombin light and heavy chains ===
=== Hirugen + Thrombin light and heavy chains ===
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[[2zhe]], [[2zhf]], [[2zhw]], [[2zg0]], [[2zfq]], [[2zfr]], [[1c5l]], [[1hxf]], [[1hah]], [[1hai]], [[1abi]], [[1abj]], [[1hgt]], [[2uuf]] - Hirg+ hThr L&H chains<br />
[[2zhe]], [[2zhf]], [[2zhw]], [[2zg0]], [[2zfq]], [[2zfr]], [[1c5l]], [[1hxf]], [[1hah]], [[1hai]], [[1abi]], [[1abj]], [[1hgt]], [[2uuf]] - Hirg+ hThr L&H chains<br />
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=== Hirugen + Prothrombin ===
=== Hirugen + Prothrombin ===
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[[2cn0]], [[3c1k]] – Hirg+ hProThr<br />
[[2cn0]], [[3c1k]] – Hirg+ hProThr<br />
[[1t4u]], [[1t4v]], [[1o5g]], [[1g30]], [[1g32]], [[1twx]], [[3tu7]] - Hirg+hProThr+inhibitor <br />
[[1t4u]], [[1t4v]], [[1o5g]], [[1g30]], [[1g32]], [[1twx]], [[3tu7]] - Hirg+hProThr+inhibitor <br />
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=== Hirugen + Prethrombin ===
=== Hirugen + Prethrombin ===
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[[1hag]] – Hirg+hPreThr<br />
[[1hag]] – Hirg+hPreThr<br />
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=== Hirugen + Thrombin heavy chain ===
=== Hirugen + Thrombin heavy chain ===
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[[1nm6]] – Hirg+ hThr H chain<br />
[[1nm6]] – Hirg+ hThr H chain<br />
[[1nt1]] - Hirg+ hThr H chain+inhibitor<br />
[[1nt1]] - Hirg+ hThr H chain+inhibitor<br />
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== Hirugen + Thrombin light and heavy chains+inhibitor ==
== Hirugen + Thrombin light and heavy chains+inhibitor ==

Revision as of 08:46, 13 June 2012

Image:1hic.png
NMR Structure of Hirudin, 1hic

Template:STRUCTURE 1hic

Hirudin (Hir) is a powerful anticoagulant which is found in the leech salivary glands. It is an inhibitor of thrombin (Thr) which converts fibrinogen to fibrin upon blood clotting. Thrombin is produced upon enzymatic cleavage of prothrombin (ProThr). Hirugen (Hirg) is a dodecapeptide of the C-terminal of Hir (sequence NDGDFEEIPEEYL). The images at the left and at the right correspond to one representative Hirudin, i.e. the NMR Structure of Hirudin (1hic).

Contents

3D Structures of Hirudin

Update June 2012

Hirudin

1hic, 2hir, 4hir, 5hir, 6hir – Hir – NMR
2joo - Hir – NMR

Hirudin + Thrombin light and heavy chains

1hrt, 3htc, 4htc - Hir +hThr L&H chains
3da9 - Hir peptide+hThr L&H chains
3qtv, 3qwc, 3qx5 - Hir peptide + hThr L&H chains + pyridine derivative
3rlw, 3rly, 3rm0, 3rm2, 3rml, 3rmm, 3rmn, 3rmo - Hir peptide + hThr L&H chains + inhibitor
3qto - Hir +hThr L&H chains + pyridine derivative

Hirugen + Thrombin light and heavy chains

2zhe, 2zhf, 2zhw, 2zg0, 2zfq, 2zfr, 1c5l, 1hxf, 1hah, 1hai, 1abi, 1abj, 1hgt, 2uuf - Hirg+ hThr L&H chains

Hirugen + Prothrombin

2cn0, 3c1k – Hirg+ hProThr
1t4u, 1t4v, 1o5g, 1g30, 1g32, 1twx, 3tu7 - Hirg+hProThr+inhibitor

Hirugen + Prethrombin

1hag – Hirg+hPreThr

Hirugen + Thrombin heavy chain

1nm6 – Hirg+ hThr H chain
1nt1 - Hirg+ hThr H chain+inhibitor

Hirugen + Thrombin light and heavy chains+inhibitor

1fph, 7kme - Hirg +hThr L&H chains+polypeptide
1hxe - Hirg +hThr L&H chains+Rb
1ypk, 1riw, 1mu6, 1mu8, 1mue, 1no9, 1oyt, 1o2g, 1ny2, 1gj4, 1gj5, 1kts, 1ktt, 1ghv, 1ghw, 1ghx, 1ghy, 1h8i, 1h8d, 1c5n, 1c5o, 1c1u, 1c1v, 1c1w, 1qj1, 1qj6, 1qj7, 1qbv, 1bcu, 1a2c, 1a61, 1a46, 1a5g, 1b5g, 1ad8, 1ai8, 1tom, 1bmm, 1bmn, 1lhc, 1lhd, 1lhe, 1lhf, 1lhg, 1uma, 1aht, 1fpc, 3hat, 1tmu, 1dwb, 1dwc, 1dwd, 1dwe, 1tmb, 3f68, 3eq0, 3dt0, 3dux, 3dhk, 2znk, 2zo3, 3d49, 2zhq, 2zi2, 2ziq, 2zff, 2zfp, 2zgb, 2zgx, 2zf0, 2zc9, 2zda, 2zdv, 3egk, 2pw8, 3c27, 2r2m, 2cf8, 2cf9, 2bdy, 2v3h, 2v3o, 1w7g, 1ype, 1ypg, 1ypj, 3biu, 3biv, 1doj, 1ypl, 1ypm, 1vzq, 1way, 1wbg, 1k21, 1k22, 1afe, 1ae8 ,1a3b, 1a3e, 1vr1, 2bvr, 2bvs, 2bvx, 2bxt, 2bxu, 2gde, 2pks, 3ldx, 3p17 – Hirg+ hThr L&H chains+inhibitor


Hirugen+Thrombin light and heavy chains+ε-thrombin

1vit - Hirg+hThr L&H chains+epsilon-hThr


Hirugen+ α-Thrombin +inhibitor

1zrb, 1z71, 1sl3, 1ta2, 1ta6, 1zgi, 1zgv, 2uuk, 2uuj, 2jh0, 2jh5, 2jh6, 2c8w, 2c8x, 2c8y, 2c8z, 2c90, 2c93, 8kme – Hirg+α-hThr+inhibitor

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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