Catalase
From Proteopedia
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{{STRUCTURE_1gge| PDB=1gge | SIZE=400| SCENE= |right|CAPTION=E. coli catalase Hpii showing the heme group, [[1gge]] }} | {{STRUCTURE_1gge| PDB=1gge | SIZE=400| SCENE= |right|CAPTION=E. coli catalase Hpii showing the heme group, [[1gge]] }} | ||
| - | '''Catalase''' (CAT) catalyzes the conversion of hydrogen peroxide to water and oxygen. CAT contains porphyrin-heme Fe group which reacts with the hydrogen peroxide. CAT containing Mn are called pseudocatalase (PCAT). CAT KatG is a bifunctional enzyme with both catalase and peroxidase activities. CAT KatG cofactor is a heme group. It provides defense against oxidative stress by reducing hydrogen peroxide. Mutations in CAT KatG can cause resistance to the anti-malarial drug isoniazid (INH). | + | '''Catalase''' (CAT) catalyzes the conversion of hydrogen peroxide to water and oxygen. CAT contains porphyrin-heme Fe group which reacts with the hydrogen peroxide. CAT containing Mn are called pseudocatalase (PCAT). '''Catalase-peroxidase''' (CAT KatG) is a bifunctional enzyme with both catalase and peroxidase activities. CAT KatG cofactor is a heme group. It provides defense against oxidative stress by reducing hydrogen peroxide. Mutations in CAT KatG can cause resistance to the anti-malarial drug isoniazid (INH). |
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Revision as of 09:47, 20 March 2012
Catalase (CAT) catalyzes the conversion of hydrogen peroxide to water and oxygen. CAT contains porphyrin-heme Fe group which reacts with the hydrogen peroxide. CAT containing Mn are called pseudocatalase (PCAT). Catalase-peroxidase (CAT KatG) is a bifunctional enzyme with both catalase and peroxidase activities. CAT KatG cofactor is a heme group. It provides defense against oxidative stress by reducing hydrogen peroxide. Mutations in CAT KatG can cause resistance to the anti-malarial drug isoniazid (INH).
3D Structures of catalase
Updated November 2011
1qqw, 1dgb, 1dgf, 1f4j – hCAT - human
4cat – CAT – Penicillium janthinellum
1iph, 1gge, 1ye9 – EcCAT Hpii – Escherichia coli
1u2j, 1u2k – EcCAT Hpi C terminal
1u2l – EcCAT KatG
1cf9, 1qf7, 1gg9, 1ggh, 1ggj, 1ggk, 1p7y, 1p7z, 1p80, 1p81, 1qws, 3p9p, 3p9q, 3p9r, 3p9s, 3pq2, 3pq3, 3pq4, 3pq5, 3pq6, 3pq7, 3pq8, 3ttt, 3ttu, 3ttv, 3ttw, 3ttx - EcCAT Hpii (mutant)
4blc, 1tgu, 1th3, 3nwl – bCAT – Bovine
1a4e – CAT A – yeast
2cag, 1e93, 1m85, 1mqf, 1h7k – PmCAT – Proteus mirabilis
1hbz, 1gwe, 1gwf – MlCAT – Micrococcus lysodeikticus
1m7s – CAT CatF – Pseudomonas syringae
1qwl, 2iqf – HpCAT – Helicobacter pylori
1si8 – CAT – Enterococcus Faecalis
1sj2, 2cca – MtCAT – Mycobacterium tuberculosis
2ccd - MtCAT KatG (mutant)
1ub2 – CAT – Synechococcus elongatus
1mwv, 2b2o, 2b2q, 2fxg, 2fxh, 2fxj – BpCAT KatG – Burkholderia pseudomallei
1x7u, 2dv1, 2dv2, 3n3r - BpCAT KatG (mutant)
1itk, 2a9e, 3n3s – CAT – Haloarcula marismortui
1sy7 – NcCAT-1 – Neurospora crassa
3ej6 – NcCAT-3
2j2m – CAT – Exiguobacterium oxidotolerans
2isa – CAT – Vibrio salmonicida
2xf2 - 2iuf – PjCAT – Penicillium janthinellum
2xq1 – CAT – Pichia angusta
Catalase binary complexes
2cah - PmCAT + NADPH
1gwh - MlCAT + NADPH
3n3o - BpCAT KatG + NAD
1nm0 – PmCAT + formiate
1qwm - HpCAT + formic acid
1dgg – hCAT + CN
1th2 – bCAT + N3
3rgs – bCAT + NH3
2iuf – PjCAT + O
3n3n - BpCAT KatG + INH
3n3p - BpCAT KatG + INH + AMP
3n3q - BpCAT KatG + INH
3n3h - BpCAT KatG (mutant) + INH
1dgh – hCAT + amino-triazole
1th4 - bCAT + amino-triazole
1ggf - EcCAT HPII (mutant) + H2O2
Pseudocatalase Mn-containing
1jku – LpPCAT-Mn – Lactobacillus plantarum
1o9i – LpPCAT-Mn (mutant)
2cwl – TtPCAT-Mn Mn-free – Thermus thermophilus
2v8u - TtPCAT-Mn
2v8t - TtPCAT-Mn + chloride
1jkv - LpPCAT-Mn + N3
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Karsten Theis, Ann Taylor
