1u87
From Proteopedia
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{{STRUCTURE_1u87| PDB=1u87 | SCENE= }} | {{STRUCTURE_1u87| PDB=1u87 | SCENE= }} | ||
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===Crystal Structure Of The 26 Kda Glutathione S-Transferase Y7F mutant From Schistosoma Japonicum Complexed With Glutathione=== | ===Crystal Structure Of The 26 Kda Glutathione S-Transferase Y7F mutant From Schistosoma Japonicum Complexed With Glutathione=== | ||
| + | {{ABSTRACT_PUBMED_15667211}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut. | |
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==About this Structure== | ==About this Structure== | ||
[[1u87]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U87 OCA]. | [[1u87]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U87 OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Glutathione S-transferase|Glutathione S-transferase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:015667211</ref><references group="xtra"/> | + | <ref group="xtra">PMID:015667211</ref><references group="xtra"/><references/> |
[[Category: Glutathione transferase]] | [[Category: Glutathione transferase]] | ||
[[Category: Schistosoma japonicum]] | [[Category: Schistosoma japonicum]] | ||
Revision as of 08:25, 23 April 2014
Contents |
Crystal Structure Of The 26 Kda Glutathione S-Transferase Y7F mutant From Schistosoma Japonicum Complexed With Glutathione
Template:ABSTRACT PUBMED 15667211
Function
[GST26_SCHJA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
About this Structure
1u87 is a 1 chain structure with sequence from Schistosoma japonicum. Full crystallographic information is available from OCA.
See Also
Reference
- Andujar-Sanchez M, Smith AW, Clemente-Jimenez JM, Rodriguez-Vico F, Las Heras-Vazquez FJ, Jara-Perez V, Camara-Artigas A. Crystallographic and thermodynamic analysis of the binding of S-octylglutathione to the Tyr 7 to Phe mutant of glutathione S-transferase from Schistosoma japonicum. Biochemistry. 2005 Feb 1;44(4):1174-83. PMID:15667211 doi:10.1021/bi0483110
