1r9k

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[[Image:1r9k.png|left|200px]]
 
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{{STRUCTURE_1r9k| PDB=1r9k | SCENE= }}
{{STRUCTURE_1r9k| PDB=1r9k | SCENE= }}
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===Representative solution structure of the catalytic domain of SopE2===
===Representative solution structure of the catalytic domain of SopE2===
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{{ABSTRACT_PUBMED_15379540}}
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==Function==
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[[http://www.uniprot.org/uniprot/SOPE2_SALTY SOPE2_SALTY]] Activator for CDC42 by directly engaging this Rho GTPase and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells. Also activates NF-kB, p38 and ERK kinases, which are known to be involved in the induction of IL-8 expression. Chaperone InvB is required for secretion, translocation and stabilization of intracellular levels of sopE2.<ref>PMID:10931274</ref> <ref>PMID:15321998</ref>
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{{ABSTRACT_PUBMED_15379540}}
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==About this Structure==
==About this Structure==
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[[1r9k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9K OCA].
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[[1r9k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9K OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:015379540</ref><references group="xtra"/>
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<ref group="xtra">PMID:015379540</ref><references group="xtra"/><references/>
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
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[[Category: Salty]]
[[Category: Bagby, S.]]
[[Category: Bagby, S.]]
[[Category: Galyov, E E.]]
[[Category: Galyov, E E.]]

Revision as of 11:05, 16 April 2014

Template:STRUCTURE 1r9k

Contents

Representative solution structure of the catalytic domain of SopE2

Template:ABSTRACT PUBMED 15379540

Function

[SOPE2_SALTY] Activator for CDC42 by directly engaging this Rho GTPase and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells. Also activates NF-kB, p38 and ERK kinases, which are known to be involved in the induction of IL-8 expression. Chaperone InvB is required for secretion, translocation and stabilization of intracellular levels of sopE2.[1] [2]

About this Structure

1r9k is a 1 chain structure with sequence from Salty. Full experimental information is available from OCA.

Reference

  • Williams C, Galyov EE, Bagby S. solution structure, backbone dynamics, and interaction with Cdc42 of Salmonella guanine nucleotide exchange factor SopE2. Biochemistry. 2004 Sep 28;43(38):11998-2008. PMID:15379540 doi:10.1021/bi0490744
  1. ↑ Stender S, Friebel A, Linder S, Rohde M, Mirold S, Hardt WD. Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell. Mol Microbiol. 2000 Jun;36(6):1206-21. PMID:10931274
  2. ↑ Huang FC, Werne A, Li Q, Galyov EE, Walker WA, Cherayil BJ. Cooperative interactions between flagellin and SopE2 in the epithelial interleukin-8 response to Salmonella enterica serovar typhimurium infection. Infect Immun. 2004 Sep;72(9):5052-62. PMID:15321998 doi:http://dx.doi.org/10.1128/IAI.72.9.5052-5062.2004

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