4agm
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:017015838</ref><references group="xtra"/> | + | <ref group="xtra">PMID:022439615</ref><ref group="xtra">PMID:017015838</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Boeckler, F M.]] | [[Category: Boeckler, F M.]] | ||
Revision as of 18:13, 2 May 2012
Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5086
Template:ABSTRACT PUBMED 22439615
About this Structure
4agm is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Wilcken R, Liu X, Zimmermann MO, Rutherford TJ, Fersht AR, Joerger AC, Boeckler FM. Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53. J Am Chem Soc. 2012 Apr 18;134(15):6810-8. Epub 2012 Apr 5. PMID:22439615 doi:10.1021/ja301056a
- Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
