User:Olivia Cheng/Sandbox 1
From Proteopedia
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| - | There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on Serine proteases. This resemblance of the <scene name='User:Olivia_Cheng/Sandbox_1/1p4p_activesite/1'> | + | There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on Serine proteases. This resemblance of the serine protease catalytic triad consists of <scene name='User:Olivia_Cheng/Sandbox_1/1p4p_activesite/1'>Thr-166, Arg-162, and Glu-184</scene>. |
| - | + | ||
| + | The trio may cause a self-proteolysis. | ||
Revision as of 22:15, 22 March 2012
This is my sandbox!
Lyme disease
OspB Fab with H6831
|
1RJL
OspB consists of .
H6831 along with CB2 are a monoclonal antibodies.
Potential Catalytic Triad
|
1P4P
There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on Serine proteases. This resemblance of the serine protease catalytic triad consists of .
The trio may cause a self-proteolysis.
References
Becker, M. Structural Investigation of Borrelia burgodrei OspB, a BactericidalFab Target
Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections
Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis
