User:Olivia Cheng/Sandbox 1
From Proteopedia
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| + | == OspB Fab with H6831 == | ||
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This is my sandbox! | This is my sandbox! | ||
---- | ---- | ||
| + | Outer Surface Protein B (OspB) is a component | ||
| - | Lyme disease | ||
| + | <Structure load='1RJL' size='500' frame='true' align='right' caption='[http://proteopedia.com/wiki/index.php/1rjl 1RJL] with Chain C in purple and Chains A, B, and D white' scene='User:Olivia_Cheng/Sandbox_1/1rjl_color/1'/> | ||
| - | == OspB Fab with H6831 == | ||
| + | Click here to revert to the <scene name='User:Olivia_Cheng/Sandbox_1/1rjl_color/1'>original model</scene>. | ||
| - | <Structure load='1RJL' size='500' frame='true' align='right' caption='[http://proteopedia.com/wiki/index.php/1rjl Model of 1RJL] with Chain C in purple and Chains A, B, and D white' scene='User:Olivia_Cheng/Sandbox_1/1rjl_color/1'/> | ||
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| + | <!--Monoclonal antibodies LINK | ||
| + | [http://www.proteopedia.org/wiki/index.php/Monoclonal_antibody Monoclonal antibodies] | ||
| + | --> | ||
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| + | == Potential Catalytic Triad == | ||
| + | <!-- | ||
| + | 1P4P link | ||
| + | --> | ||
| - | == | + | <Structure load='1P4P' size='500' frame='true' align='right' caption='1P4P' scene='[http://proteopedia.com/wiki/index.php/1p4p 1P4P]' /> |
| - | <Structure load='1P4P' size='500' frame='true' align='right' caption='1P4P' scene='Insert optional scene name here' /> | ||
| - | 1P4P | ||
<scene name='User:Olivia_Cheng/Sandbox_1/1p4p_lys253/1'>Lys-253</scene> | <scene name='User:Olivia_Cheng/Sandbox_1/1p4p_lys253/1'>Lys-253</scene> | ||
| - | There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on | + | There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on [http://en.wikipedia.org/wiki/Serine_protease Serine proteases]. |
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== References == | == References == | ||
| - | + | Becker M, Bunikis J, Lade BD, Dunn JJ, Barbour AG, Lawson CL. Structural investigation of ''Borrelia burgdorferi'' OspB, a bactericidal Fab target. J Biol Chem. 2005 Apr 29;280(17):17363-70. Epub 2005 Feb 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15713683 15713683] doi:[http://www.jbc.org/content/280/17/17363 10.1074/jbc.M412842200] | |
| - | Becker M, Bunikis J, Lade BD, Dunn JJ, Barbour AG, Lawson CL. Structural investigation of ''Borrelia burgdorferi'' OspB, a bactericidal Fab target. J Biol Chem. 2005 Apr 29;280(17):17363-70. Epub 2005 Feb 15. PMID:15713683 doi:10.1074/jbc.M412842200 | + | |
Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections | Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections | ||
Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis | Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis | ||
Revision as of 05:21, 25 March 2012
OspB Fab with H6831
This is my sandbox!
Outer Surface Protein B (OspB) is a component
|
Click here to revert to the .
OspB consists of .
H6831 along with CB2 are a monoclonal antibodies.
Potential Catalytic Triad
|
There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on Serine proteases.
References
Becker M, Bunikis J, Lade BD, Dunn JJ, Barbour AG, Lawson CL. Structural investigation of Borrelia burgdorferi OspB, a bactericidal Fab target. J Biol Chem. 2005 Apr 29;280(17):17363-70. Epub 2005 Feb 15. PMID:15713683 doi:10.1074/jbc.M412842200
Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections
Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis
