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1zcd

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[[Image:1zcd.png|left|200px]]
 
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{{STRUCTURE_1zcd| PDB=1zcd | SCENE= }}
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===Crystal structure of the Na+/H+ antiporter NhaA===
===Crystal structure of the Na+/H+ antiporter NhaA===
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{{ABSTRACT_PUBMED_15988517}}
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==Function==
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[[http://www.uniprot.org/uniprot/NHAA_ECOLI NHAA_ECOLI]] Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 2 H(+) per Na(+). Can mediate sodium uptake when a transmembrane pH gradient is applied. Active at alkaline pH. Activity is strongly down-regulated below pH 6.5.<ref>PMID:1645730</ref>
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{{ABSTRACT_PUBMED_15988517}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:015988517</ref><ref group="xtra">PMID:016919297</ref><references group="xtra"/>
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<ref group="xtra">PMID:015988517</ref><references group="xtra"/><references/>
[[Category: Complex I]]
[[Category: Complex I]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]

Revision as of 08:39, 23 April 2014

Template:STRUCTURE 1zcd

Contents

Crystal structure of the Na+/H+ antiporter NhaA

Template:ABSTRACT PUBMED 15988517

Function

[NHAA_ECOLI] Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 2 H(+) per Na(+). Can mediate sodium uptake when a transmembrane pH gradient is applied. Active at alkaline pH. Activity is strongly down-regulated below pH 6.5.[1]

About this Structure

1zcd is a 2 chain structure with sequence from Escherichia coli. The December 2011 RCSB PDB Molecule of the Month feature on Complex I by David Goodsell is 10.2210/rcsb_pdb/mom_2011_12. Full crystallographic information is available from OCA.

Reference

  • Hunte C, Screpanti E, Venturi M, Rimon A, Padan E, Michel H. Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH. Nature. 2005 Jun 30;435(7046):1197-202. PMID:15988517 doi:10.1038/nature03692
  1. ↑ Taglicht D, Padan E, Schuldiner S. Overproduction and purification of a functional Na+/H+ antiporter coded by nhaA (ant) from Escherichia coli. J Biol Chem. 1991 Jun 15;266(17):11289-94. PMID:1645730

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