User:Olivia Cheng/Sandbox 1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (→OspB Interaction with Fab of H6831)
m
Line 1: Line 1:
-
This is my sandbox!
+
--[[User:Olivia Cheng|Olivia Cheng]] 23:30, 27 March 2012 (IST)This is my sandbox!
----
----
Line 25: Line 25:
H6831 along with CB2 are a monoclonal antibodies.
H6831 along with CB2 are a monoclonal antibodies.
 +
 +
 +
H6831 appears to have a bactericidal effect on OspB in the absence of complement proteins.
 +
 +
 +
 +
 +
 +
 +
 +
 +
 +
 +
 +
 +
 +
 +
 +
 +
 +
 +
 +
 +
 +
 +
Line 44: Line 70:
-
<scene name='User:Olivia_Cheng/Sandbox_1/1p4p_lys253/1'>Lys-253</scene>
+
Proposed Mechanism
-
There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on [http://en.wikipedia.org/wiki/Serine_protease Serine proteases].
+
 
 +
<scene name='User:Olivia_Cheng/Sandbox_1/1p4p_lys253/1'>Lys-253</scene>
 +
There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on [http://en.wikipedia.org/wiki/Serine_protease Serine proteasoccur.

Revision as of 21:30, 27 March 2012

--Olivia Cheng 23:30, 27 March 2012 (IST)This is my sandbox!

Outer Surface Protein B (OspB) is a component


Hemoglobin

OspB Interaction with Fab of H6831

1RJL with Chain C in purple and Chains A, B, and D white

Drag the structure with the mouse to rotate


Click here to revert to the .


OspB consists of .

H6831 along with CB2 are a monoclonal antibodies.


H6831 appears to have a bactericidal effect on OspB in the absence of complement proteins.















Potential Catalytic Triad

Drag the structure with the mouse to rotate


Proposed Mechanism



There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on [http://en.wikipedia.org/wiki/Serine_protease Serine proteasoccur.




References

Becker M, Bunikis J, Lade BD, Dunn JJ, Barbour AG, Lawson CL. Structural investigation of Borrelia burgdorferi OspB, a bactericidal Fab target. J Biol Chem. 2005 Apr 29;280(17):17363-70. Epub 2005 Feb 15. PMID:15713683 doi:10.1074/jbc.M412842200

Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections

Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis

Proteopedia Page Contributors and Editors (what is this?)

Olivia Cheng

Retrieved from "http://52.214.119.220/wiki/index.php/User:Olivia_Cheng/Sandbox_1"
Personal tools