3g7d

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[[Image:3g7d.png|left|200px]]
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==Native PhpD with Cadmium Atoms==
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<StructureSection load='3g7d' size='340' side='right' caption='[[3g7d]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3g7d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_viridochromogenes Streptomyces viridochromogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G7D FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene><br>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Phosphinothricin biosynthetic cluster, phpD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1938 Streptomyces viridochromogenes])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g7d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g7d RCSB], [http://www.ebi.ac.uk/pdbsum/3g7d PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Natural products containing phosphorus-carbon bonds have found widespread use in medicine and agriculture. One such compound, phosphinothricin tripeptide, contains the unusual amino acid phosphinothricin attached to two alanine residues. Synthetic phosphinothricin (glufosinate) is a component of two top-selling herbicides (Basta and Liberty), and is widely used with resistant transgenic crops including corn, cotton and canola. Recent genetic and biochemical studies showed that during phosphinothricin tripeptide biosynthesis 2-hydroxyethylphosphonate (HEP) is converted to hydroxymethylphosphonate (HMP). Here we report the in vitro reconstitution of this unprecedented C(sp(3))-C(sp(3)) bond cleavage reaction and X-ray crystal structures of the enzyme. The protein is a mononuclear non-haem iron(ii)-dependent dioxygenase that converts HEP to HMP and formate. In contrast to most other members of this family, the oxidative consumption of HEP does not require additional cofactors or the input of exogenous electrons. The current study expands the scope of reactions catalysed by the 2-His-1-carboxylate mononuclear non-haem iron family of enzymes.
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An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis.,Cicchillo RM, Zhang H, Blodgett JA, Whitteck JT, Li G, Nair SK, van der Donk WA, Metcalf WW Nature. 2009 Jun 11;459(7248):871-4. PMID:19516340<ref>PMID:19516340</ref>
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The line below this paragraph, containing "STRUCTURE_3g7d", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3g7d| PDB=3g7d | SCENE= }}
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===Native PhpD with Cadmium Atoms===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19516340}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19516340 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_19516340}}
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==About this Structure==
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[[3g7d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_viridochromogenes Streptomyces viridochromogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G7D OCA].
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==Reference==
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<ref group="xtra">PMID:019516340</ref><references group="xtra"/>
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[[Category: Streptomyces viridochromogenes]]
[[Category: Streptomyces viridochromogenes]]
[[Category: Nair, S K.]]
[[Category: Nair, S K.]]
[[Category: Biosynthetic protein]]
[[Category: Biosynthetic protein]]
[[Category: Cupin]]
[[Category: Cupin]]

Revision as of 09:43, 21 May 2014

Native PhpD with Cadmium Atoms

3g7d, resolution 1.80Å

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