4a8j

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[[Image:4a8j.png|left|200px]]
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==Crystal Structure of the Elongator subcomplex Elp456==
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<StructureSection load='4a8j' size='340' side='right' caption='[[4a8j]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4a8j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A8J FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a8j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a8j RCSB], [http://www.ebi.ac.uk/pdbsum/4a8j PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Elongator was initially described as an RNA polymerase II-associated factor but has since been associated with a broad range of cellular activities. It has also attracted clinical attention because of its role in certain neurodegenerative diseases. Here we describe the crystal structure of the Saccharomyces cerevisiae subcomplex of Elongator proteins 4, 5 and 6 (Elp456). The subunits each show almost identical RecA folds that form a heterohexameric ring-like structure resembling hexameric RecA-like ATPases. This structural finding is supported by different complementary in vitro and in vivo approaches, including the specific binding of the hexameric Elp456 subcomplex to tRNAs in a manner regulated by ATP. Our results support a role of Elongator in tRNA modification, explain the importance of each of the Elp4, Elp5 and Elp6 subunits for complex integrity and suggest a model for the overall architecture of the holo-Elongator complex.
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The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase.,Glatt S, Letoquart J, Faux C, Taylor NM, Seraphin B, Muller CW Nat Struct Mol Biol. 2012 Feb 19;19(3):314-20. doi: 10.1038/nsmb.2234. PMID:22343726<ref>PMID:22343726</ref>
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The line below this paragraph, containing "STRUCTURE_4a8j", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_4a8j| PDB=4a8j | SCENE= }}
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===Crystal Structure of the Elongator subcomplex Elp456===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22343726}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22343726 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22343726}}
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==About this Structure==
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[[4a8j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A8J OCA].
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==Reference==
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<ref group="xtra">PMID:022343726</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Glatt, S.]]
[[Category: Glatt, S.]]
[[Category: Mueller, C W.]]
[[Category: Mueller, C W.]]
[[Category: Transcription]]
[[Category: Transcription]]

Revision as of 07:22, 5 June 2014

Crystal Structure of the Elongator subcomplex Elp456

4a8j, resolution 2.10Å

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