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2c12

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[[Image:2c12.png|left|200px]]
 
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{{STRUCTURE_2c12| PDB=2c12 | SCENE= }}
{{STRUCTURE_2c12| PDB=2c12 | SCENE= }}
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===Crystal Structure of Nitroalkane Oxidase in Complex with Spermine, a Competitive Inhibitor===
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{{ABSTRACT_PUBMED_16430210}}
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===CRYSTAL STRUCTURE OF NITROALKANE OXIDASE IN COMPLEX WITH SPERMINE, A COMPETITIVE INHIBITOR===
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==Function==
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[[http://www.uniprot.org/uniprot/NAO_FUSOX NAO_FUSOX]] Catalyzes the oxidative denitrification of neutral nitroalkanes, including 3-nitro-2-pentanol, 1-nitropropane, 2-nitropropane, nitroethane and nitrocyclohexane, and may thereby protect the organism against toxic compounds. Has no detectable acyl-CoA dehydrogenase activity.<ref>PMID:11867731</ref> <ref>PMID:22538</ref> <ref>PMID:16430210</ref>
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{{ABSTRACT_PUBMED_16430210}}
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==About this Structure==
==About this Structure==
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[[2c12]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusarium_oxysporum Fusarium oxysporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C12 OCA].
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[[2c12]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusox Fusox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C12 OCA].
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==See Also==
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*[[Group:MUZIC:ANKRD2|MUZIC:ANKRD2]]
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==Reference==
==Reference==
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<ref group="xtra">PMID:016430210</ref><ref group="xtra">PMID:015272176</ref><ref group="xtra">PMID:015581574</ref><references group="xtra"/>
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<ref group="xtra">PMID:016430210</ref><references group="xtra"/><references/>
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[[Category: Fusarium oxysporum]]
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[[Category: Fusox]]
[[Category: Fitzpatrick, P F.]]
[[Category: Fitzpatrick, P F.]]
[[Category: Nagpal, A.]]
[[Category: Nagpal, A.]]

Revision as of 05:50, 4 December 2013

Template:STRUCTURE 2c12

Contents

Crystal Structure of Nitroalkane Oxidase in Complex with Spermine, a Competitive Inhibitor

Template:ABSTRACT PUBMED 16430210

Function

[NAO_FUSOX] Catalyzes the oxidative denitrification of neutral nitroalkanes, including 3-nitro-2-pentanol, 1-nitropropane, 2-nitropropane, nitroethane and nitrocyclohexane, and may thereby protect the organism against toxic compounds. Has no detectable acyl-CoA dehydrogenase activity.[1] [2] [3]

About this Structure

2c12 is a 6 chain structure with sequence from Fusox. Full crystallographic information is available from OCA.

Reference

  • Nagpal A, Valley MP, Fitzpatrick PF, Orville AM. Crystal structures of nitroalkane oxidase: insights into the reaction mechanism from a covalent complex of the flavoenzyme trapped during turnover. Biochemistry. 2006 Jan 31;45(4):1138-50. PMID:16430210 doi:10.1021/bi051966w
  1. ↑ Daubner SC, Gadda G, Valley MP, Fitzpatrick PF. Cloning of nitroalkane oxidase from Fusarium oxysporum identifies a new member of the acyl-CoA dehydrogenase superfamily. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2702-7. Epub 2002 Feb 26. PMID:11867731 doi:http://dx.doi.org/10.1073/pnas.052527799
  2. ↑ Kido T, Hashizume K, Soda K. Purification and properties of nitroalkane oxidase from Fusarium oxysporum. J Bacteriol. 1978 Jan;133(1):53-8. PMID:22538
  3. ↑ Nagpal A, Valley MP, Fitzpatrick PF, Orville AM. Crystal structures of nitroalkane oxidase: insights into the reaction mechanism from a covalent complex of the flavoenzyme trapped during turnover. Biochemistry. 2006 Jan 31;45(4):1138-50. PMID:16430210 doi:10.1021/bi051966w

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