2c12
From Proteopedia
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{{STRUCTURE_2c12| PDB=2c12 | SCENE= }} | {{STRUCTURE_2c12| PDB=2c12 | SCENE= }} | ||
| + | ===Crystal Structure of Nitroalkane Oxidase in Complex with Spermine, a Competitive Inhibitor=== | ||
| + | {{ABSTRACT_PUBMED_16430210}} | ||
| - | == | + | ==Function== |
| - | + | [[http://www.uniprot.org/uniprot/NAO_FUSOX NAO_FUSOX]] Catalyzes the oxidative denitrification of neutral nitroalkanes, including 3-nitro-2-pentanol, 1-nitropropane, 2-nitropropane, nitroethane and nitrocyclohexane, and may thereby protect the organism against toxic compounds. Has no detectable acyl-CoA dehydrogenase activity.<ref>PMID:11867731</ref> <ref>PMID:22538</ref> <ref>PMID:16430210</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | [[2c12]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[2c12]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusox Fusox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C12 OCA]. |
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:016430210</ref>< | + | <ref group="xtra">PMID:016430210</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Fusox]] |
[[Category: Fitzpatrick, P F.]] | [[Category: Fitzpatrick, P F.]] | ||
[[Category: Nagpal, A.]] | [[Category: Nagpal, A.]] | ||
Revision as of 05:50, 4 December 2013
Contents |
Crystal Structure of Nitroalkane Oxidase in Complex with Spermine, a Competitive Inhibitor
Template:ABSTRACT PUBMED 16430210
Function
[NAO_FUSOX] Catalyzes the oxidative denitrification of neutral nitroalkanes, including 3-nitro-2-pentanol, 1-nitropropane, 2-nitropropane, nitroethane and nitrocyclohexane, and may thereby protect the organism against toxic compounds. Has no detectable acyl-CoA dehydrogenase activity.[1] [2] [3]
About this Structure
2c12 is a 6 chain structure with sequence from Fusox. Full crystallographic information is available from OCA.
Reference
- Nagpal A, Valley MP, Fitzpatrick PF, Orville AM. Crystal structures of nitroalkane oxidase: insights into the reaction mechanism from a covalent complex of the flavoenzyme trapped during turnover. Biochemistry. 2006 Jan 31;45(4):1138-50. PMID:16430210 doi:10.1021/bi051966w
- ↑ Daubner SC, Gadda G, Valley MP, Fitzpatrick PF. Cloning of nitroalkane oxidase from Fusarium oxysporum identifies a new member of the acyl-CoA dehydrogenase superfamily. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2702-7. Epub 2002 Feb 26. PMID:11867731 doi:http://dx.doi.org/10.1073/pnas.052527799
- ↑ Kido T, Hashizume K, Soda K. Purification and properties of nitroalkane oxidase from Fusarium oxysporum. J Bacteriol. 1978 Jan;133(1):53-8. PMID:22538
- ↑ Nagpal A, Valley MP, Fitzpatrick PF, Orville AM. Crystal structures of nitroalkane oxidase: insights into the reaction mechanism from a covalent complex of the flavoenzyme trapped during turnover. Biochemistry. 2006 Jan 31;45(4):1138-50. PMID:16430210 doi:10.1021/bi051966w
