4dag

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[[Image:4dag.png|left|200px]]
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==Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site==
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<StructureSection load='4dag' size='340' side='right' caption='[[4dag]], [[Resolution|resolution]] 3.39&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4dag]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_metapneumovirus Human metapneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DAG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DAG FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IGHG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IGL@ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dag OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dag RCSB], [http://www.ebi.ac.uk/pdbsum/4dag PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human metapneumovirus and respiratory syncytial virus cause lower respiratory tract infections. The virus fusion (F) glycoprotein promotes membrane fusion by refolding from a metastable pre-fusion to a stable post-fusion conformation. F is also a major target of the neutralizing antibody response. Here we show that a potently neutralizing anti-human metapneumovirus antibody (DS7) binds a structurally invariant domain of F, revealing a new epitope that could be targeted in vaccine development.
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Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site.,Wen X, Krause JC, Leser GP, Cox RG, Lamb RA, Williams JV, Crowe JE Jr, Jardetzky TS Nat Struct Mol Biol. 2012 Mar 4. doi: 10.1038/nsmb.2250. PMID:22388735<ref>PMID:22388735</ref>
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The line below this paragraph, containing "STRUCTURE_4dag", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_4dag| PDB=4dag | SCENE= }}
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===Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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<!--
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*[[Antibody|Antibody]]
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The line below this paragraph, {{ABSTRACT_PUBMED_22388735}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 22388735 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_22388735}}
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</StructureSection>
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==About this Structure==
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[[4dag]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_metapneumovirus Human metapneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DAG OCA].
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==Reference==
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<ref group="xtra">PMID:022388735</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Human metapneumovirus]]
[[Category: Human metapneumovirus]]

Revision as of 07:54, 5 June 2014

Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site

4dag, resolution 3.39Å

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