1ice
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor | + | Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor to the proinflammatory cytokine, interleukin-1 beta, and may regulate programmed cell death in neuronal cells. The high-resolution structure of human ICE in complex with an inhibitor has been determined by X-ray diffraction. The structure confirms the relationship between human ICE and cell-death proteins in other organisms. The active site spans both the 10 and 20K subunits, which associate to form a tetramer, suggesting a mechanism for ICE autoactivation. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Caspases]] | [[Category: Caspases]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Griffith, J | + | [[Category: Griffith, J P.]] |
| - | [[Category: Kim, E | + | [[Category: Kim, E E.]] |
| - | [[Category: Navia, M | + | [[Category: Navia, M A.]] |
| - | [[Category: Wilson, K | + | [[Category: Wilson, K P.]] |
[[Category: ACE]] | [[Category: ACE]] | ||
[[Category: cytokine]] | [[Category: cytokine]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:10:22 2008'' |
Revision as of 11:10, 21 February 2008
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STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME
Overview
Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor to the proinflammatory cytokine, interleukin-1 beta, and may regulate programmed cell death in neuronal cells. The high-resolution structure of human ICE in complex with an inhibitor has been determined by X-ray diffraction. The structure confirms the relationship between human ICE and cell-death proteins in other organisms. The active site spans both the 10 and 20K subunits, which associate to form a tetramer, suggesting a mechanism for ICE autoactivation.
About this Structure
1ICE is a Single protein structure of sequence from [1] with as ligand. The following page contains interesting information on the relation of 1ICE with [Caspases]. Active as Caspase-1, with EC number 3.4.22.36 Full crystallographic information is available from OCA.
Reference
Structure and mechanism of interleukin-1 beta converting enzyme., Wilson KP, Black JA, Thomson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, et al., Nature. 1994 Jul 28;370(6487):270-5. PMID:8035875
Page seeded by OCA on Thu Feb 21 13:10:22 2008
Categories: Caspase-1 | Caspases | Single protein | Griffith, J P. | Kim, E E. | Navia, M A. | Wilson, K P. | ACE | Cytokine
