3ri4

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[[Image:3ri4.jpg|left|200px]]
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==Ets1 cooperative binding to widely separated sites on promoter DNA==
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<StructureSection load='3ri4' size='340' side='right' caption='[[3ri4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ri4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RI4 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3mfk|3mfk]], [[1gvj|1gvj]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ETS1, EWSR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ri4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ri4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ri4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ri4 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ets1 is a member of the Ets family of transcription factors. Ets1 is expressed in autoinhibited form and its DNA binding depends on partner proteins bound to adjacent sequences or the relative positioning of a second Ets-binding site (EBS). The autoinhibition of Ets1 is mediated by structural coupling of regions flanking the DNA-binding domain. The NMR structure of Ets1 revealed that the inhibitory regions comprised of helices HI1 and HI2 and H4 are packed together on the Ets domain to form an inhibitory module. The crystal structure of Ets1 unexpectedly revealed a homodimer in which homodimerisation occurs via swapping of HI1 helices. Modeling of DNA binding indicates that the Ets1 dimer can bind to two antiparallel pieces of DNA. To verify this, we crystallized and solved the structure of the complex comprised of Ets1 dimer and two pieces of DNA. DNA binding by Ets1 dimer resulted in formation of additional intermolecular protein*DNA interactions, implying that the complex formation is cooperative.
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Structural basis of ets1 cooperative binding to widely separated sites on promoter DNA.,Babayeva ND, Baranovskaya OI, Tahirov TH PLoS One. 2012;7(3):e33698. Epub 2012 Mar 14. PMID:22432043<ref>PMID:22432043</ref>
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The line below this paragraph, containing "STRUCTURE_3ri4", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3ri4| PDB=3ri4 | SCENE= }}
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===Ets1 cooperative binding to widely separated sites on promoter DNA===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22432043}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22432043 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22432043}}
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==About this Structure==
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[[3ri4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RI4 OCA].
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==Reference==
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<ref group="xtra">PMID:022432043</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Babayeva, N D.]]
[[Category: Babayeva, N D.]]

Revision as of 04:51, 5 June 2014

Ets1 cooperative binding to widely separated sites on promoter DNA

3ri4, resolution 3.00Å

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