2lnv

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[[Image:2lnv.png|left|200px]]
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==Solution structure of GspC-HR of typeII secretion system==
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<StructureSection load='2lnv' size='340' side='right' caption='[[2lnv]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lnv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dickeya_dadantii Dickeya dadantii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNV OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">outC, Dda3937_02414 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=204038 Dickeya dadantii])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lnv RCSB], [http://www.ebi.ac.uk/pdbsum/2lnv PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The type II secretion system of Gram-negative bacteria is important for bacterial pathogenesis and survival; it is composed of 12 mostly multimeric core proteins, which build a sophisticated secretion machine spanning both bacterial membranes. OutC is the core component of the inner membrane subcomplex thought to be involved in both recognition of substrate and interaction with the outer membrane secretin OutD. Here, we report the solution structure of the HR domain of OutC and explore its interaction with the secretin. The HR domain adopts a beta-sandwich-like fold consisting of two beta-sheets each composed of three anti-parallel beta-strands. This structure is strikingly similar to the periplasmic region of PilP, an inner membrane lipoprotein from the type IV pilus system highlighting the common evolutionary origin of these two systems and showing that all the core components of the type II secretion system have a structural or sequence ortholog within the type IV pili system. The HR domain is shown to interact with the N0 domain of the secretin. The importance of this interaction is explored in the context of the functional secretion system.
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Solution Structure of Homology Region (HR) Domain of Type II Secretion System.,Gu S, Kelly G, Wang X, Frenkiel T, Shevchik VE, Pickersgill RW J Biol Chem. 2012 Mar 16;287(12):9072-80. Epub 2012 Jan 17. PMID:22253442<ref>PMID:22253442</ref>
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The line below this paragraph, containing "STRUCTURE_2lnv", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2lnv| PDB=2lnv | SCENE= }}
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===Solution structure of GspC-HR of typeII secretion system===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22253442}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22253442 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22253442}}
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==About this Structure==
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[[2lnv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dickeya_dadantii Dickeya dadantii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNV OCA].
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==Reference==
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<ref group="xtra">PMID:022253442</ref><references group="xtra"/>
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[[Category: Dickeya dadantii]]
[[Category: Dickeya dadantii]]
[[Category: Gu, S.]]
[[Category: Gu, S.]]

Revision as of 08:31, 7 May 2014

Solution structure of GspC-HR of typeII secretion system

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