2jhc

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[[Category: virion protein]]
[[Category: virion protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:06:28 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:34:17 2007''

Revision as of 15:29, 30 October 2007

Image:2jhc.gif

2jhc, resolution 3.00Å

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THE STRUCTURE OF BLUETONGUE VIRUS VP4 REVEALS A MULTIFUNCTIONAL RNA-CAPPING PRODUCTION-LINE

Overview

Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series, of four chemical reactions. Some viruses achieve this using a single, molecule; the crystal structure of such an enzyme from bluetongue virus, reveals an elongated modular architecture that provides a scaffold for an, assemblage of active sites, two contributed by a domain of novel, structure.

About this Structure

2JHC is a [Single protein] structure of sequence from [Bluetongue virus 10 (isolate usa)] with GUN as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Bluetongue virus VP4 is an RNA-capping assembly line., Sutton G, Grimes JM, Stuart DI, Roy P, Nat Struct Mol Biol. 2007 May;14(5):449-51. Epub 2007 Apr 8. PMID:17417654

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