3qde

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[[Image:3qde.png|left|200px]]
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==The structure of Cellobiose phosphorylase from Clostridium thermocellum in complex with phosphate==
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<StructureSection load='3qde' size='340' side='right' caption='[[3qde]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qde]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_thermocellum Clostridium thermocellum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QDE FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=144:TRIS-HYDROXYMETHYL-METHYL-AMMONIUM'>144</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cbp, Q8VP44 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1515 Clostridium thermocellum])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellobiose_phosphorylase Cellobiose phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.20 2.4.1.20] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qde OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qde RCSB], [http://www.ebi.ac.uk/pdbsum/3qde PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Clostridium thermocellum is a cellulosome-producing bacterium that is able to efficiently degrade and utilize cellulose as a sole carbon source. Cellobiose phosphorylase (CBP) plays a critical role in cellulose degradation by catalyzing the reversible phosphate-dependent hydrolysis of cellobiose, the major product of cellulose degradation, into alpha-D-glucose 1-phosphate and D-glucose. CBP from C. thermocellum is a modular enzyme composed of four domains [N-terminal domain, helical linker, (alpha/alpha)(6)-barrel domain and C-terminal domain] and is a member of glycoside hydrolase family 94. The 2.4 A resolution X-ray crystal structure of C. thermocellum CBP reveals the residues involved in coordinating the catalytic phosphate as well as the residues that are likely to be involved in substrate binding and discrimination.
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Structure of cellobiose phosphorylase from Clostridium thermocellum in complex with phosphate.,Bianchetti CM, Elsen NL, Fox BG, Phillips GN Jr Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1345-9., Epub 2011 Oct 25. PMID:22102229<ref>PMID:22102229</ref>
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The line below this paragraph, containing "STRUCTURE_3qde", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_3qde| PDB=3qde | SCENE= }}
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===The structure of Cellobiose phosphorylase from Clostridium thermocellum in complex with phosphate===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22102229}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22102229 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22102229}}
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==About this Structure==
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[[3qde]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_thermocellum Clostridium thermocellum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QDE OCA].
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==Reference==
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<ref group="xtra">PMID:022102229</ref><references group="xtra"/>
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[[Category: Cellobiose phosphorylase]]
[[Category: Cellobiose phosphorylase]]
[[Category: Clostridium thermocellum]]
[[Category: Clostridium thermocellum]]

Revision as of 05:22, 4 June 2014

The structure of Cellobiose phosphorylase from Clostridium thermocellum in complex with phosphate

3qde, resolution 2.40Å

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