Sandbox Reserved 489

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Renin is secreted by the kidneys. The kidneys act both directly and indirectly to regulate arterial blood pressure and provide the major long term mechanism of blood pressure and control. The direct mechanism changes blood volume independently of hormones. When blood pressure and blood volume increase the kidneys can not filter all of the liquids and thus liquids are lost in the urine to decrease blood pressure and blood volume.
Renin is secreted by the kidneys. The kidneys act both directly and indirectly to regulate arterial blood pressure and provide the major long term mechanism of blood pressure and control. The direct mechanism changes blood volume independently of hormones. When blood pressure and blood volume increase the kidneys can not filter all of the liquids and thus liquids are lost in the urine to decrease blood pressure and blood volume.
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The indirect mechanism, or the [http://en.wikipedia.org/wiki/Renin-angiotensin_system renin-angiotensin system] (RAS), controls blood volume and blood pressure through renin and two forms of [http://en.wikipedia.org/wiki/Angiotensin angiotensin]. Renin is involved in the first step of a cascade that eventually produces angiotensin II. The specialized granular cells of the [http://en.wikipedia.org/wiki/Juxtaglomerular_apparatus juxtaglomerular apparatus] secrete renin when stimulated by
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The indirect mechanism, or the [http://en.wikipedia.org/wiki/Renin-angiotensin_system renin-angiotensin system] (RAS), controls blood volume and blood pressure through renin and two forms of [http://en.wikipedia.org/wiki/Angiotensin angiotensin]. Renin is involved in the first step of a cascade that eventually produces angiotensin II. The specialized granular cells of the [http://en.wikipedia.org/wiki/Juxtaglomerular_apparatus juxtaglomerular apparatus] secrete renin when stimulated by the [http://en.wikipedia.org/wiki/Macula_densa macula densa] when blood pressure or blood volume decreases.

Revision as of 19:58, 13 April 2012

This Sandbox is Reserved from 13/03/2012, through 01/06/2012 for use in the course "Proteins and Molecular Mechanisms" taught by Robert B. Rose at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 451 through Sandbox Reserved 500.
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Renin

Renin, also known as angiotensinogenase, is an aspartyl protease and belongs to the protein family peptidase A1. Aspartyl proteases are endopeptidases that typically use two aspartate residues in the active site in a reduction-oxidation reaction with water to specifically cleave peptide substrates. Mature renin circulates in the blood and contains 406 amino acid residues and has a mass of approximately 37 kDa. The function of renin is to cleave the angiotensin I precursor, angiotensinogen, to produce angiotensin I.

Renin is secreted by the kidneys. The kidneys act both directly and indirectly to regulate arterial blood pressure and provide the major long term mechanism of blood pressure and control. The direct mechanism changes blood volume independently of hormones. When blood pressure and blood volume increase the kidneys can not filter all of the liquids and thus liquids are lost in the urine to decrease blood pressure and blood volume.

The indirect mechanism, or the renin-angiotensin system (RAS), controls blood volume and blood pressure through renin and two forms of angiotensin. Renin is involved in the first step of a cascade that eventually produces angiotensin II. The specialized granular cells of the juxtaglomerular apparatus secrete renin when stimulated by the macula densa when blood pressure or blood volume decreases.

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