Sandbox Reserved 429
From Proteopedia
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===Overall Structure=== | ===Overall Structure=== | ||
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<scene name='Sandbox_Reserved_429/Secondary_structure_highlight/1'>Secondary Structures Highlighted</scene> | <scene name='Sandbox_Reserved_429/Secondary_structure_highlight/1'>Secondary Structures Highlighted</scene> | ||
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===Binding Interactions=== | ===Binding Interactions=== | ||
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<scene name='Sandbox_Reserved_429/Disulfide_bonds/1'>Disulfides bonds</scene> | <scene name='Sandbox_Reserved_429/Disulfide_bonds/1'>Disulfides bonds</scene> | ||
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===Additional Features=== | ===Additional Features=== | ||
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1. Mutations in NOG | 1. Mutations in NOG | ||
Revision as of 19:40, 14 April 2012
| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
Contents |
YourMacromolecule
Introduction
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1. Basic info (size, ligand name)
2. Origin (Zebrafish?)
3. Relation to disease (Metastatic Prostate cancer, kidney disease)
4. Pharmaceutical Applications
Overall Structure
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1. Size of Protein
2. AA distribution
3. How many Domains
4. Number and locations of Alpha Helices, Beta Strands
5. Other pieces (non AA)
6. Primary Structure? Secondary? Tertiary?
Binding Interactions
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Outline
1. BMP7-Noggin Complex
2.Conformational changes due to binding
3. Hydrophilic and hydrophobic pockets
4. Receptor 1 & 2 and Finger 1 & 2
5. Others Antagonist of BMP 7
6. Binding affinity in comparison to others BMP families
7. Overall Summary of how binding affects overall pathways for bone formation
Additional Features
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1. Mutations in NOG
a.Substitutions of six positions :Pro35Arg, Cys184Tyr, Gly189Cys, Ile220Asn, Tyr222Cys/ Tyr222Asn, Pro223Leu affect folding stability
b. Pro35Arg - decreased affinity, diminished inhibition of chondrogenesis
c. Pro35Ser- similar
2. BMP regulators evolution -BMP signalling pathway, gene duplication ligand receptor - structural homology between agonists and antagonists
Credits
Introduction - Alec
Overall Structure - William
Drug Binding Site - Felix
Additional Features - Paula
