3ubm

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[[Image:3ubm.png|left|200px]]
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==Formyl-CoA:oxalate CoA-transferase from Acetobacter aceti==
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<StructureSection load='3ubm' size='340' side='right' caption='[[3ubm]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ubm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Acetobacter_aceti Acetobacter aceti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UBM FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">uctB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435 Acetobacter aceti])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ubm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ubm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ubm RCSB], [http://www.ebi.ac.uk/pdbsum/3ubm PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacterial formyl-CoA:oxalate CoA-transferase (FCOCT) and oxalyl-CoA decarboxylase work in tandem to perform a proton-consuming decarboxylation that has been suggested to have a role in generalized acid resistance. FCOCT is the product of uctB in the acidophilic acetic acid bacterium Acetobacter aceti. As expected for an acid-resistance factor, UctB remains folded at the low pH values encountered in the A. aceti cytoplasm. A comparison of crystal structures of FCOCTs and related proteins revealed few features in UctB that would distinguish it from non-acidophilic proteins and thereby account for its acid stability properties, other than a strikingly featureless electrostatic surface. The apparently neutral surface is a result of a "speckled" charge decoration, in which charged surface residues are surrounded by compensating charges but do not form salt bridges. A quantitative comparison among orthologues identified a pattern of residue substitution in UctB that may be a consequence of selection for protein stability by constant exposure to acetic acid. We suggest that this surface charge pattern, which is a distinctive feature of A. aceti proteins, creates a stabilizing electrostatic network without stiffening the protein or compromising protein-solvent interactions.
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Formyl-coenzyme A (CoA): Oxalate CoA-transferase from the acidophile Acetobacter aceti has a distinctive electrostatic surface and inherent acid stability.,Mullins EA, Starks CM, Francois JA, Sael L, Kihara D, Kappock TJ Protein Sci. 2012 Feb 28. doi: 10.1002/pro.2054. PMID:22374910<ref>PMID:22374910</ref>
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The line below this paragraph, containing "STRUCTURE_3ubm", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3ubm| PDB=3ubm | SCENE= }}
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===Formyl-CoA:oxalate CoA-transferase from Acetobacter aceti===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22374910}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22374910 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22374910}}
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==About this Structure==
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[[3ubm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Acetobacter_aceti Acetobacter aceti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UBM OCA].
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==Reference==
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<ref group="xtra">PMID:022374910</ref><references group="xtra"/>
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[[Category: Acetobacter aceti]]
[[Category: Acetobacter aceti]]
[[Category: Kappock, T J.]]
[[Category: Kappock, T J.]]

Revision as of 06:41, 5 June 2014

Formyl-CoA:oxalate CoA-transferase from Acetobacter aceti

3ubm, resolution 1.99Å

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